Literature DB >> 8242226

PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells.

G Bkaily1, P d'Orléans-Juste, R Naik, J Pérodin, J Stankova, E Abdulnour, M Rola-Pleszczynski.   

Abstract

By the use of fura-2 and digital imaging techniques, [K]o depolarization or PAF (10(-9) M) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) that was insensitive to nifedipine but sensitive to (-)-PN200-110 or to lowering of [Ca]o. The PAF-induced effect on [Ca]i was blocked by the PAF receptor antagonist, WEB2170. Our results suggest that [K]o depolarization and PAF increase [Ca]i via the activation of R-type Ca2+ channels.

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Year:  1993        PMID： 8242226      PMCID： PMC2175959          DOI： 10.1111/j.1476-5381.1993.tb13841.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

Review 1.  Voltage-dependent and agonist-activated ionic currents in vascular endothelial cells: a review.

Authors:  K Takeda; M Klepper
Journal:  Blood Vessels       Date:  1990

Review 2.  Voltage-gated and receptor-mediated ionic currents in the membrane of endothelial cells.

Authors:  P D Bregestovski; U S Ryan
Journal:  J Mol Cell Cardiol       Date:  1989-02       Impact factor: 5.000

3.  Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells.

Authors:  R Jacob; J E Merritt; T J Hallam; T J Rink
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4.  Blockade of insulin sensitive steady-state R-type Ca2+ channel by PN 200-110 in heart and vascular smooth muscle.

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5.  Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo.

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Authors:  J Striessnig; K Moosburger; A Goll; D R Ferry; H Glossmann
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  6 in total
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5.  Role of R-type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet-activating factor.

Authors:  A Claing; G Bkaily; N Berthiaume; P Sirois; M Rola-Pleszczynski; P D'Orléans-Juste
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  5 in total

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