| Literature DB >> 3412458 |
R Jacob1, J E Merritt, T J Hallam, T J Rink.
Abstract
Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.Entities:
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Year: 1988 PMID： 3412458 DOI： 10.1038/335040a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962