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Literature DB >> 8241470

Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor.

Abstract

Double-stranded RNA (dsRNA) adenosine deaminase, or DRADA, is a cellular enzyme that modifies adenosine residues to inosines in dsRNA by hydrolytic deamination, replacing A-U with mismatched I-U base pairs. Since it alters the base composition in its substrate RNA, one possible role played by DRADA is to participate in RNA editing. In this article, a brief review is given of characteristics of DRADA. Its possible involvement in RNA editing is also discussed in detail, including specific cases in which DRADA has been implicated as an RNA editing factor.

Entities: Chemical Gene Species

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Year: 1993 PMID： 8241470 DOI： 10.1006/scel.1993.1034

Source DB: PubMed Journal: Semin Cell Biol ISSN： 1043-4682

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Cited

11 in total

1. Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.

Authors: M Kumar; G G Carmichael
Journal: Proc Natl Acad Sci U S A Date: 1997-04-15 Impact factor: 11.205

2. Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.

Authors: Y Liu; C E Samuel
Journal: J Virol Date: 1996-03 Impact factor: 5.103

Review 3. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.

Authors: Jennifer L Hood; Ronald B Emeson
Journal: Curr Top Microbiol Immunol Date: 2012 Impact factor: 4.291

4. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

Authors: A Herb; M Higuchi; R Sprengel; P H Seeburg
Journal: Proc Natl Acad Sci U S A Date: 1996-03-05 Impact factor: 11.205

5. The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification.

Authors: L Saccomanno; B L Bass
Journal: Mol Cell Biol Date: 1994-08 Impact factor: 4.272

10. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.

Authors: J B Patterson; C E Samuel
Journal: Mol Cell Biol Date: 1995-10 Impact factor: 4.272

Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor.

1. Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.

2. Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.

Review 3. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.

4. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

5. The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification.

Review 6. Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.

7. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

8. Nucleotide sequence stability of the genome of hepatitis delta virus.

9. Editing of the GLuR-B ion channel RNA in vitro by recombinant double-stranded RNA adenosine deaminase.

10. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.