Literature DB >> 8240655

Bis-naphthalimides: a new class of antitumor agents.

M F Braña1, J M Castellano, M Morán, M J Pérez de Vega, C R Romerdahl, X D Qian, P Bousquet, F Emling, E Schlick, G Keilhauer.   

Abstract

A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.

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Year:  1993        PMID： 8240655

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


  10 in total

1.  Mode-of-action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus.

Authors:  Thomas M Menzel; Maximilian Tischer; Patrice François; Joachim Nickel; Jacques Schrenzel; Heike Bruhn; Annette Albrecht; Leane Lehmann; Ulrike Holzgrabe; Knut Ohlsen
Journal:  Antimicrob Agents Chemother       Date:  2010-10-11       Impact factor: 5.191

2.  High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones.

Authors:  Michael B Tropak; Jan E Blanchard; Stephen G Withers; Eric D Brown; Don Mahuran
Journal:  Chem Biol       Date:  2007-02

3.  Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma.

Authors:  Livia Rosa-Fernandes; Sueli Mieko Oba-Shinjo; Janaina Macedo-da-Silva; Suely Kazue Nagahashi Marie; Giuseppe Palmisano
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

4.  4-Amino-1,8-naphthalimide-ferrocene conjugates as potential multi-targeted anticancer and fluorescent cellular imaging agents.

Authors:  Alex D Johnson; Joseph A Buhagiar; David C Magri
Journal:  RSC Med Chem       Date:  2021-10-21

5.  6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis.

Authors:  Asama Mukherjee; Sushanta Dutta; Muthiah Shanmugavel; Dilip M Mondhe; Parduman R Sharma; Shashank K Singh; Ajit K Saxena; Utpal Sanyal
Journal:  J Exp Clin Cancer Res       Date:  2010-12-31

6.  Anticancer activity expressed by a library of 2,9-diazaperopyrenium dications.

Authors:  Karel J Hartlieb; Leah S Witus; Daniel P Ferris; Ashish N Basuray; Mohammed M Algaradah; Amy A Sarjeant; Charlotte L Stern; Majed S Nassar; Youssry Y Botros; J Fraser Stoddart
Journal:  ACS Nano       Date:  2015-01-23       Impact factor: 15.881

7.  Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates.

Authors:  Iwona E Głowacka; Rafał Gulej; Piotr Grzonkowski; Graciela Andrei; Dominique Schols; Robert Snoeck; Dorota G Piotrowska
Journal:  Molecules       Date:  2016-10-26       Impact factor: 4.411

8.  Synthesis and antimicrobial activity of some new pyrimidinone and oxazinone derivatives fused with thiophene rings using 2-chloro-6-ethoxy-4-acetylpyridine as starting material.

Authors:  Aisha S M Hossan; Hanaa M A Abu-Melha; Mohamed A Al-Omar; Abd El-Galil E Amr
Journal:  Molecules       Date:  2012-11-19       Impact factor: 4.411

9.  Cytotoxicity evaluation of a new set of 2-aminobenzo[de]iso-quinoline-1,3-diones.

Authors:  Rashad Al-Salahi; Ibrahim Alswaidan; Mohamed Marzouk
Journal:  Int J Mol Sci       Date:  2014-12-04       Impact factor: 5.923

10.  Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis.

Authors:  Elif Keskin; Mehmet Hikmet Ucisik; Bilgesu Onur Sucu; Mustafa Guzel
Journal:  Molecules       Date:  2019-12-16       Impact factor: 4.411
  10 in total

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