Literature DB >> 8240231

9-cis-retinoic acid is a natural antagonist for the retinoic acid receptor response pathway.

C Carlberg1, J H Saurat, G Siegenthaler.   

Abstract

The pleiotropic activities of retinoids are mediated by two types of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). All-trans-retinoic acid (RA) transcriptionally activates RARs, but not RXRs, whereas its natural stereoisomer, 9-cis-RA, is the ligand for RXRs. Here, we demonstrate that 9-cis-RA did not transcriptionally activate RARs, whereas in the presence of all-trans-RA the transactivation of RARs was inhibited in a dose-dependent manner by 9-cis-RA. RAR homodimer complexes were destabilized in vitro in the presence of 9-cis-RA. This suggests that 9-cis-RA may be a natural antagonist of all-trans-RA for binding to RAR complexes. The levels of 9-cis-RA may determine by which pathway the transcription of retinoid-responsive genes is modulated.

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Year:  1993        PMID： 8240231      PMCID： PMC1134887          DOI： 10.1042/bj2950343

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

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Journal:  Nature       Date:  1990-01-11       Impact factor: 49.962

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Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

7.  H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

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Journal:  Cell       Date:  1992-10-02       Impact factor: 41.582

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Authors:  N Brand; M Petkovich; A Krust; P Chambon; H de Thé; A Marchio; P Tiollais; A Dejean
Journal:  Nature       Date:  1988-04-28       Impact factor: 49.962

Review 10.  The steroid and thyroid hormone receptor superfamily.

Authors:  R M Evans
Journal:  Science       Date:  1988-05-13       Impact factor: 47.728
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  8 in total

1.  The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor.

Authors:  C Carlberg
Journal:  Endocrine       Date:  1996-04       Impact factor: 3.633

2.  Differential effects of 9-cis and all-trans retinoic acid on the induction of retinoic acid receptor-beta and cellular retinoic acid-binding protein II in human neuroblastoma cells.

Authors:  C P Redfern; P E Lovat; A J Malcolm; A D Pearson
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

3.  Study of O-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid.

Authors:  P Reboul; P George; D Miquel; P Louisot; P Broquet
Journal:  Glycoconj J       Date:  1996-02       Impact factor: 2.916

4.  A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.

Authors:  J Labrecque; F Dumas; A Lacroix; P V Bhat
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

5.  Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand.

Authors:  I Wiesenberg; M Missbach; J P Kahlen; M Schräder; C Carlberg
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971

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Authors:  B B Jones; C K Ohno; G Allenby; M B Boffa; A A Levin; J F Grippo; M Petkovich
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Authors:  M Schräder; S Nayeri; J P Kahlen; K M Müller; C Carlberg
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

Review 8.  Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans.

Authors:  Torsten Bohn; Charles Desmarchelier; Lars O Dragsted; Charlotte S Nielsen; Wilhelm Stahl; Ralph Rühl; Jaap Keijer; Patrick Borel
Journal:  Mol Nutr Food Res       Date:  2017-02-27       Impact factor: 5.914
  8 in total

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