Literature DB >> 8785491

Study of O-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid.

P Reboul1, P George, D Miquel, P Louisot, P Broquet.   

Abstract

When treated with retinoic acid in vivo, C6 glioma cells show an enhancement of CMP-Neu5Ac:Gal beta 1-3 GalNAc-R alpha-2,3 sialyltransferase activity. A 300 kDa glycoprotein was detected by lectin affinoblotting in retinoic acid-treated C6 cells which stained weakly or not at all in control cells. Comparative studies with different lectins demonstrated that this glycoprotein contains alpha 2,3 Neu5Ac Gal-GalNAc O-glycan moieties. Cultures in the presence of an inhibitor of O-glycan synthesis (N-acetylgalactosaminide alpha-O-benzyl) demonstrated that enhancement of staining of the 300 kDa glycoprotein was not due to the increase of the alpha 2,3 sialytransferase but to the de novo synthesis of the polypeptide chain of this glycoprotein.

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Year:  1996        PMID： 8785491     DOI： 10.1007/bf01049682

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  57 in total

1.  Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.

Authors:  V Giguère; S Lyn; P Yip; C H Siu; S Amin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  Modulation by all-trans retinoic acid of glycoprotein glycosylation in murine melanoma cells: enhancement of fucosyl- and galactosyltransferase activities.

Authors:  B Amos; V Deutsch; R Lotan
Journal:  Cancer Biochem Biophys       Date:  1990-01

3.  Evidence for an O-glycan sialylation system in brain. Characterization of a beta-galactoside alpha 2,3-sialyltransferase from rat brain regulating the expression of an alpha-N-acetylgalactosaminide alpha 2,6-sialyltransferase activity.

Authors:  H Baubichon-Cortay; P Broquet; P George; P Louisot
Journal:  Eur J Biochem       Date:  1989-06-15

4.  Inhibition of mucin glycosylation by aryl-N-acetyl-alpha-galactosaminides in human colon cancer cells.

Authors:  S F Kuan; J C Byrd; C Basbaum; Y S Kim
Journal:  J Biol Chem       Date:  1989-11-15       Impact factor: 5.157

5.  Structure of the disaccharide chain of galactosyl-N-acetylgalactosaminyl-protein synthesized in vitro.

Authors:  D H van den Eijnden; R A Barneveld; W E Schiphorst
Journal:  Eur J Biochem       Date:  1979-04

6.  Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture.

Authors:  C Labbaye; M Valtieri; U Testa; A Giampaolo; E Meccia; P Sterpetti; I Parolini; E Pelosi; D Bulgarini; Y E Cayre
Journal:  Blood       Date:  1994-02-01       Impact factor: 22.113

Review 7.  The retinoid receptors.

Authors:  S M Pemrick; D A Lucas; J F Grippo
Journal:  Leukemia       Date:  1994-11       Impact factor: 11.528

8.  Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism.

Authors:  P D Fiorella; J L Napoli
Journal:  J Biol Chem       Date:  1991-09-05       Impact factor: 5.157

9.  Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells.

Authors:  N Kojima; K Handa; W Newman; S Hakomori
Journal:  Biochem Biophys Res Commun       Date:  1992-02-14       Impact factor: 3.575

10.  Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

Authors:  D J Mangelsdorf; U Borgmeyer; R A Heyman; J Y Zhou; E S Ong; A E Oro; A Kakizuka; R M Evans
Journal:  Genes Dev       Date:  1992-03       Impact factor: 11.361
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  1 in total

1.  Retinoic acid induction of sialyltransferase activity in neuroblastoma cells of differing sialylation potentials.

Authors:  N Georgopoulou; K C Breen
Journal:  Glycoconj J       Date:  2000-11       Impact factor: 2.916
  1 in total

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