Literature DB >> 8239627

Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

J R Menninger1, R A Coleman.   

Abstract

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of peptidyl-tRNA. Lincomycin and clindamycin stimulated peptidyl-tRNA dissociation from ribosomes.

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Year:  1993        PMID： 8239627      PMCID： PMC188116          DOI： 10.1128/AAC.37.9.2027

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits.

Authors:  M L. Celma; R E. Monro; D Vazquez
Journal:  FEBS Lett       Date:  1971-03-16       Impact factor: 4.124

2.  Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes.

Authors:  M L. Celma; R E. Monro; D Vazquez
Journal:  FEBS Lett       Date:  1970-02-16       Impact factor: 4.124

3.  The accumulation as peptidyl-transfer RNA of isoaccepting transfer RNA families in Escherichia coli with temperature-sensitive peptidyl-transfer RNA hydrolase.

Authors:  J R Menninger
Journal:  J Biol Chem       Date:  1978-10-10       Impact factor: 5.157

4.  Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.

Authors:  A G Atherly; J R Menninger
Journal:  Nat New Biol       Date:  1972-12-20

5.  Studies on the metabolic role of peptidyl-tRNA hydrolase. I. Properties of a mutant E. coli with temperature-sensitive peptidyl-tRNA hydrolase.

Authors:  J R Menninger; C Walker; P F Tan
Journal:  Mol Gen Genet       Date:  1973-03-19

6.  Studies on transfer ribonucleic acid-ribosome complexes. XIX. Effect of antibiotics on peptidyl puromycin synthesis on polyribosoms from Escherichia coli.

Authors:  S Pestka
Journal:  J Biol Chem       Date:  1972-07-25       Impact factor: 5.157

7.  Polysome metabolism in Escherichia coli: effect of antibiotics on polysome stability.

Authors:  H L Ennis
Journal:  Antimicrob Agents Chemother       Date:  1972-03       Impact factor: 5.191

8.  Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis.

Authors:  R E Monro; D Vazquez
Journal:  J Mol Biol       Date:  1967-08-28       Impact factor: 5.469

Review 9.  Mechanism of action of spiramycin and other macrolides.

Authors:  A Brisson-Noël; P Trieu-Cuot; P Courvalin
Journal:  J Antimicrob Chemother       Date:  1988-07       Impact factor: 5.790

10.  Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes.

Authors:  J R Menninger; D P Otto
Journal:  Antimicrob Agents Chemother       Date:  1982-05       Impact factor: 5.191
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  6 in total

1.  Inhibition of translation and cell growth by minigene expression.

Authors:  T Tenson; J V Herrera; P Kloss; G Guarneros; A S Mankin
Journal:  J Bacteriol       Date:  1999-03       Impact factor: 3.490

Review 2.  Throwing a spanner in the works: antibiotics and the translation apparatus.

Authors:  C M Spahn; C D Prescott
Journal:  J Mol Med (Berl)       Date:  1996-08       Impact factor: 4.599

3.  Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.

Authors:  E Schmitt; Y Mechulam; M Fromant; P Plateau; S Blanquet
Journal:  EMBO J       Date:  1997-08-01       Impact factor: 11.598

Review 4.  Bacterial transfer RNAs.

Authors:  Jennifer Shepherd; Michael Ibba
Journal:  FEMS Microbiol Rev       Date:  2015-03-21       Impact factor: 16.408

5.  Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.

Authors:  Farid El'Garch; Katy Jeannot; Didier Hocquet; Catherine Llanes-Barakat; Patrick Plésiat
Journal:  Antimicrob Agents Chemother       Date:  2006-12-28       Impact factor: 5.191

6.  Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing.

Authors:  J R Menninger; R A Coleman; L N Tsai
Journal:  Mol Gen Genet       Date:  1994-04
  6 in total

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