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Literature DB >> 8239625

Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.

G Arlet¹, M Rouveau, G Fournier, P H Lagrange, A Philippon.

Abstract

A clinical isolate of Klebsiella pneumoniae was more resistant to aztreonam than to cefotaxime and ceftazidime. It produced a clavulanate-susceptible beta-lactamase with an isoelectric point of 6.3 which readily hydrolyzed penicillins, cefotaxime, and ceftazidime, but which hydrolyzed aztreonam poorly. The enzyme was encoded by a gene on a 15-kb plasmid; the gene hybridized with an intragenic DNA probe of blaTEM.

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Year: 1993 PMID： 8239625 PMCID： PMC188114 DOI： 10.1128/AAC.37.9.2020

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Journal: J Clin Microbiol Date: 1984-10 Impact factor: 5.948

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Journal: Antimicrob Agents Chemother Date: 1978-04 Impact factor: 5.191

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Journal: J Antimicrob Chemother Date: 1987-09 Impact factor: 5.790

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Journal: Rev Infect Dis Date: 1988 Jul-Aug

9. Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.

Authors: C M Chanal; D L Sirot; A Petit; R Labia; A Morand; J L Sirot; R A Cluzel
Journal: Antimicrob Agents Chemother Date: 1989-11 Impact factor: 5.191

10. Properties of PSE-2 beta-lactamase and genetic basis for its production in Pseudomonas aeruginosa.

Authors: A M Philippon; G C Paul; G A Jacoby
Journal: Antimicrob Agents Chemother Date: 1983-09 Impact factor: 5.191

5 in total

1. Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.

Authors: G Arlet; S Goussard; P Courvalin; A Philippon
Journal: Antimicrob Agents Chemother Date: 1999-04 Impact factor: 5.191

2. Clonal and horizontal dissemination of Klebsiella pneumoniae expressing SHV-5 extended-spectrum beta-lactamase in a Mexican pediatric hospital.

Authors: Guadalupe Miranda; Natividad Castro; Blanca Leaños; Adriana Valenzuela; Ulises Garza-Ramos; Teresa Rojas; Fortino Solórzano; Lilia Chihu; Jesús Silva
Journal: J Clin Microbiol Date: 2004-01 Impact factor: 5.948