Literature DB >> 8234438

Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients.

O Kinnunen1, I Winblad, P Koistinen, J Salokannel.   

Abstract

Thirty geriatric long-stay patients aged 65-94 years (mean 81.8) participated in the trial the aim of which was to examine bulk laxative plus senna (Agiolax) in the treatment of chronic constipation using lactulose (Levolac) as a reference medicine. Bulk laxative plus senna (daily doses 14.8 g) produced more frequent (p < 0.05) bowel habits (4.5 vs. 2.2-1.9/week) than lactulose (daily doses 20.1 g). Both laxatives proved to be safe to use. Our study indicated bulk laxative plus senna to be more efficient in treating constipation in geriatric long-stay patients.

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Year:  1993        PMID： 8234438     DOI： 10.1159/000139866

Source DB:  PubMed          Journal:  Pharmacology        ISSN： 0031-7012            Impact factor:   2.547


  19 in total

1.  Lack of objective evidence of efficacy of laxatives in chronic constipation.

Authors:  Michael P Jones; Nicholas J Talley; Guy Nuyts; Dominique Dubois
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199

Review 2.  Recommendations on chronic constipation (including constipation associated with irritable bowel syndrome) treatment.

Authors:  P Paré; Ronald Bridges; Malcolm C Champion; Subhas C Ganguli; James R Gray; E Jan Irvine; Victor Plourde; Pierre Poitras; Geoffrey K Turnbull; Paul Moayyedi; Nigel Flook; Stephen M Collins
Journal:  Can J Gastroenterol       Date:  2007-04       Impact factor: 3.522

Review 3.  What's the 'best buy' for treatment of constipation? Results of a systematic review of the efficacy and comparative efficacy of laxatives in the elderly.

Authors:  M Petticrew; I Watt; M Brand
Journal:  Br J Gen Pract       Date:  1999-05       Impact factor: 5.386

4.  Review of efficacy and safety of laxatives use in geriatrics.

Authors:  Manhal Izzy; Anju Malieckal; Erin Little; Sury Anand
Journal:  World J Gastrointest Pharmacol Ther       Date:  2016-05-06

5.  Economic impact of low dose polyethylene glycol 3350 plus electrolytes compared with lactulose in the management of idiopathic constipation in the UK.

Authors:  Angela H Christie; Pearl Culbert; Julian F Guest
Journal:  Pharmacoeconomics       Date:  2002       Impact factor: 4.981

6.  Systematic Review: FDA-Approved Prescription Medications for Adults With Constipation.

Authors:  Brooks D Cash; Brian E Lacy
Journal:  Gastroenterol Hepatol (N Y)       Date:  2006-10

Review 7.  Holistic Approach to Functional Constipation: Perspective of Traditional Persian Medicine.

Authors:  Majid Nimrouzi; Mohammad M Zarshenas
Journal:  Chin J Integr Med       Date:  2015-11-23       Impact factor: 1.978

8.  Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment).

Authors:  Antonio Bove; Massimo Bellini; Edda Battaglia; Renato Bocchini; Dario Gambaccini; Vincenzo Bove; Filippo Pucciani; Donato Francesco Altomare; Giuseppe Dodi; Guido Sciaudone; Ezio Falletto; Vittorio Piloni
Journal:  World J Gastroenterol       Date:  2012-09-28       Impact factor: 5.742

Review 9.  Epidemiology of constipation in elderly patients. Drug utilisation and cost-containment strategies.

Authors:  F A Lederle
Journal:  Drugs Aging       Date:  1995-06       Impact factor: 3.923

10.  Pharmacoeconomic Impact of Low-Dose Macrogol 3350 plus Electrolytes Compared with Lactulose in the Management of Chronic Idiopathic Constipation among Ambulant Patients in Belgium.

Authors:  Julian F Guest; Susan J Varney
Journal:  Clin Drug Investig       Date:  2004       Impact factor: 2.859
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