Literature DB >> 8230807

In vitro gametocytocidal activity of artemisinin and its derivatives on Plasmodium falciparum.

N Mehra1, V K Bhasin.   

Abstract

Artemisinin and six of its derivatives were evaluated for their in vitro gametocytocidal and erythrocytic schizontocidal properties on an Indian isolate of Plasmodium falciparum. One of the metabolic derivatives, DADF-dihydroartemisinin (NIH02), was found to possess gametocytocidal and erythrocytic schizontocidal properties similar to those of artemisinin. Gametocytes of this isolate were highly susceptible to the toxic effect of NIH02 (IC50 = 6.6 ng/ml) and younger stages were more sensitive. This is the first report about the in vitro gametocytocidal properties of a derivative of artemisinin.

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Year:  1993        PMID： 8230807     DOI： 10.7883/yoken1952.46.37

Source DB:  PubMed          Journal:  Jpn J Med Sci Biol        ISSN： 0021-5112


  10 in total

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Review 4.  Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

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Review 6.  Progress in the research of artemisinin-related antimalarials: an update.

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7.  Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria.

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Review 8.  The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis.

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10.  Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children.

Authors:  Abdoulaye A Djimde; Amelia W Maiga; Dinkorma Ouologuem; Bakary Fofana; Issaka Sagara; Demba Dembele; Sekou Toure; Kassim Sanogo; Souleymane Dama; Bakary Sidibe; Ogobara K Doumbo
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  10 in total

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