Literature DB >> 8229005

GM3 regulates protein kinase systems in cultured brain microvascular endothelial cells.

T Kanda1, T Ariga, M Yamawaki, R K Yu.   

Abstract

The barrier function of endothelial cells is known to be positively regulated by protein kinase A (PKA) and negatively regulated by protein kinase C (PKC). We found that exogenously administered GM3(NeuAc) promoted PKA activity in cultured brain microvascular endothelial cells (BMECs). Other glycolipids, including GM1, sulfoglucuronyl paragloboside, and GM3(NeuGc), did not have any effect on the PKA activity of BMECs. PC12 cells did not respond to exogenously applied GM3(NeuAc). GM3(NeuAc) also suppressed the PKC activity of BMECs. Thus, GM3(NeuAc) may function as a modulator of blood-brain barrier function via the two different kinase systems.

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Year:  1993        PMID： 8229005     DOI： 10.1111/j.1471-4159.1993.tb09842.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  6 in total

1.  Glycosyltransferase activities in cultured endothelial cells of bovine brain microvascular origin.

Authors:  T Kanda; T Ariga; M Yamawaki; H Yoshino; X B Gu; R K Yu
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

Review 2.  The role of globo-series glycolipids in neuronal cell differentiation--a review.

Authors:  T Ariga; R K Yu
Journal:  Neurochem Res       Date:  1998-03       Impact factor: 3.996

3.  Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.

Authors:  G Zeng; T Ariga; X B Gu; R K Yu
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205

4.  Ganglioside composition of the rat choriocarcinoma cell line, Rcho-1.

Authors:  T Shirai; S Itonori; T Tai; M J Soares; K Shiota; T Ogawa
Journal:  Glycoconj J       Date:  1996-06       Impact factor: 2.916

5.  Ceramide signaling in cancer and stem cells.

Authors:  Erhard Bieberich
Journal:  Future Lipidol       Date:  2008-06

6.  Glycosphingolipid antigens in cultured bovine brain microvascular endothelial cells: sulfoglucuronosyl paragloboside as a target of monoclonal IgM in demyelinative neuropathy [corrected].

Authors:  T Kanda; H Yoshino; T Ariga; M Yamawaki; R K Yu
Journal:  J Cell Biol       Date:  1994-07       Impact factor: 10.539
  6 in total

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