Literature DB >> 7567994

Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.

G Zeng1, T Ariga, X B Gu, R K Yu.   

Abstract

Treatment of the human promyelocytic leukemia cell line HL-60 with antisense oligodeoxynucleotides to UDP-N-acetylgalactosamine:beta-1,4-N-acetylgalactosaminyl-transferase (GM2-synthase; EC 2.4.1.92) and CMP-sialic acid:alpha-2,8-sialyltransferase (GD3-synthase; EC 2.4.99.8) sequences effectively down-regulated the synthesis of more complex gangliosides in the ganglioside synthetic pathways after GM3, resulting in a remarkable increase in endogenous GM3 with concomitant decreases in more complex gangliosides. The treated cells underwent monocytic differentiation as judged by morphological changes, adherent ability, and nitroblue tetrazolium staining. These data provide evidence that the increased endogenous ganglioside GM3 may play an important role in regulating cellular differentiation and that the antisense DNA technique proves to be a powerful tool in manipulating glycolipid synthesis in the cell.

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Year:  1995        PMID： 7567994      PMCID： PMC41028          DOI： 10.1073/pnas.92.19.8670

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

Review 1.  THE GANGLIOSIDES.

Authors:  L SVENNERHOLM
Journal:  J Lipid Res       Date:  1964-04       Impact factor: 5.922

2.  Glycolipids.

Authors:  M Basu; T De; K K Das; J W Kyle; H C Chon; R J Schaeper; S Basu
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

3.  Nitroblue-tetrazolium tests.

Authors:  A W Segal
Journal:  Lancet       Date:  1974-11-23       Impact factor: 79.321

Review 4.  Gangliosides: structure, isolation, and analysis.

Authors:  R W Ledeen; R K Yu
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

Review 5.  Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.

Authors:  S Hakomori
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

6.  Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

Authors:  E G Bremer; J Schlessinger; S Hakomori
Journal:  J Biol Chem       Date:  1986-02-15       Impact factor: 5.157

7.  Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

Authors:  E L Wickstrom; T A Bacon; A Gonzalez; D L Freeman; G H Lyman; E Wickstrom
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

8.  Activation of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase during the differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate.

Authors:  T Momoi; M Shinmoto; J Kasuya; H Senoo; Y Suzuki
Journal:  J Biol Chem       Date:  1986-12-05       Impact factor: 5.157

9.  Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937.

Authors:  H Nojiri; F Takaku; Y Terui; Y Miura; M Saito
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

10.  Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

Authors:  T R Breitman; S E Selonick; S J Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205
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  9 in total

1.  GM1 synthase depends on N-glycosylation for enzyme activity and trafficking to the Golgi complex.

Authors:  J A Martina; J L Daniotti; H J Maccioni
Journal:  Neurochem Res       Date:  2000-05       Impact factor: 3.996

2.  Compartmental organization of the synthesis of GM3, GD3, and GM2 in golgi membranes from neural retina cells.

Authors:  M K Maxzúd; H J Maccioni
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

3.  A lineage-specific protein kinase crucial for myeloid maturation.

Authors:  D Semizarov; D Glesne; A Laouar; K Schiebel; E Huberman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

Review 4.  Biosynthesis and functions of gangliosides: recent advances.

Authors:  K O Lloyd; K Furukawa
Journal:  Glycoconj J       Date:  1998-07       Impact factor: 2.916

Review 5.  The role of globo-series glycolipids in neuronal cell differentiation--a review.

Authors:  T Ariga; R K Yu
Journal:  Neurochem Res       Date:  1998-03       Impact factor: 3.996

6.  Mannosylerythritol lipid induces granulocytic differentiation and inhibits the tyrosine phosphorylation of human myelogenous leukemia cell line K562.

Authors:  H Isoda; T Nakahara
Journal:  Cytotechnology       Date:  1997-11       Impact factor: 2.058

7.  Differentiation of human promyelocytic leukemia cell line HL60 by microbial extracellular glycolipids.

Authors:  H Isoda; H Shinmoto; D Kitamoto; M Matsumura; T Nakahara
Journal:  Lipids       Date:  1997-03       Impact factor: 1.880

Review 8.  Cloning and transcriptional regulation of genes responsible for synthesis of gangliosides.

Authors:  Guichao Zeng; Robert K Yu
Journal:  Curr Drug Targets       Date:  2008-04       Impact factor: 3.465

9.  Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis.

Authors:  Concepción Gómez-Moutón; Rosa Ana Lacalle; Emilia Mira; Sonia Jiménez-Baranda; Domingo F Barber; Ana C Carrera; Carlos Martínez-A; Santos Mañes
Journal:  J Cell Biol       Date:  2004-02-23       Impact factor: 10.539
  9 in total

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