AIMS: To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations. METHODS: Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inflammation and the presence of H pylori was determined, and serology to evaluate PG I and II concentrations and IgG titres to H pylori was carried out. RESULTS: The presence of H pylori was strongly correlated with high IgG antibody titres to H pylori and gastritis. Patients who were H pylori positive had significantly higher PG I and PG II concentrations and a significantly lower PG I:PG II ratio than patients who were negative for H pylori. In 13 patients with duodenal ulcer and H pylori positive gastritis serum PG I concentrations were significantly higher than in H pylori positive patients without duodenal ulcer. Significant correlations were found between the age of patients and serum PG II, the PG I:PG II ratio, IgG antibodies to H pylori, the severity of body gastritis and H pylori infection, and between the degree of gastritis in the body of the stomach and the PG II concentration. CONCLUSIONS: Serum PG I and II concentrations, together with a fall in the PG I:PG II ratio, could be used as predictors of H pylori infection as well as serum IgG antibody response to H pylori.
AIMS: To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations. METHODS: Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inflammation and the presence of H pylori was determined, and serology to evaluate PG I and II concentrations and IgG titres to H pylori was carried out. RESULTS: The presence of H pylori was strongly correlated with high IgG antibody titres to H pylori and gastritis. Patients who were H pylori positive had significantly higher PG I and PG II concentrations and a significantly lower PG I:PG II ratio than patients who were negative for H pylori. In 13 patients with duodenal ulcer and H pylori positive gastritis serum PG I concentrations were significantly higher than in H pylori positive patients without duodenal ulcer. Significant correlations were found between the age of patients and serum PG II, the PG I:PG II ratio, IgG antibodies to H pylori, the severity of body gastritis and H pylori infection, and between the degree of gastritis in the body of the stomach and the PG II concentration. CONCLUSIONS: Serum PG I and II concentrations, together with a fall in the PG I:PG II ratio, could be used as predictors of H pylori infection as well as serum IgG antibody response to H pylori.
Authors: J I Rotter; J Q Sones; I M Samloff; C T Richardson; J M Gursky; J H Walsh; D L Rimoin Journal: N Engl J Med Date: 1979-01-11 Impact factor: 91.245
Authors: I L Taylor; J Calam; J I Rotter; C Vaillant; I M Samloff; A Cook; E Simkin; G J Dockray Journal: Ann Intern Med Date: 1981-10 Impact factor: 25.391
Authors: J I Rotter; G Petersen; I M Samloff; R B McConnell; A Ellis; M A Spence; D L Rimoin Journal: Ann Intern Med Date: 1979-09 Impact factor: 25.391
Authors: M Menegatti; J Holton; N Figura; G Biasco; C Ricci; G Oderda; R Conte; M Miglioli; D Vaira Journal: Dig Dis Sci Date: 1998-11 Impact factor: 3.199
Authors: D Vaira; J Holton; M Menegatti; F Landi; C Ricci; A Ali; L Gatta; S Farinelli; C Acciardi; B Massardi; M Miglioli Journal: Gut Date: 1998-07 Impact factor: 23.059