AIM: To investigate the association between Helicobacter pylori infection and serum pepsinogen (PG) 1 and 2 concentrations in various gastroduodenal diseases. METHODS: Serum PG1 and 2 concentrations and antibodies to H pylori were measured by enzyme linked immunosorbent assay (ELISA); gastric mucosal pH was assessed and urease activity in biopsy tissue was determined. A comparison of the ELISA and urease test results permitted division of the cases into positive, false positive, false negative and negative categories for control, gastritis, and ulcer groups. RESULTS: The gastric mucosal pH and serum PG2 in cases positive for H pylori were significantly increased in ulcer and gastritis cases compared with H pylori negative cases. Similar tendencies were observed for the false positive and false negative categories. CONCLUSIONS: A positive ELISA reaction for antibodies and an increased serum PG2 concentration are reliable indicators of H pylori infection.
AIM: To investigate the association between Helicobacter pyloriinfection and serum pepsinogen (PG) 1 and 2 concentrations in various gastroduodenal diseases. METHODS: Serum PG1 and 2 concentrations and antibodies to H pylori were measured by enzyme linked immunosorbent assay (ELISA); gastric mucosal pH was assessed and urease activity in biopsy tissue was determined. A comparison of the ELISA and urease test results permitted division of the cases into positive, false positive, false negative and negative categories for control, gastritis, and ulcer groups. RESULTS: The gastric mucosal pH and serum PG2 in cases positive for H pylori were significantly increased in ulcer and gastritis cases compared with H pylori negative cases. Similar tendencies were observed for the false positive and false negative categories. CONCLUSIONS: A positive ELISA reaction for antibodies and an increased serum PG2 concentration are reliable indicators of H pylori infection.
Authors: C S Goodwin; E Blincow; G Peterson; C Sanderson; W Cheng; B Marshall; J R Warren; R McCulloch Journal: J Infect Dis Date: 1987-03 Impact factor: 5.226
Authors: B J Rathbone; J I Wyatt; B W Worsley; S E Shires; L K Trejdosiewicz; R V Heatley; M S Losowsky Journal: Gut Date: 1986-06 Impact factor: 23.059
Authors: Kazimierz Rembiasz; Peter C Konturek; Danuta Karcz; Stanislaw J Konturek; Władysław Ochmanski; Wladyslaw Bielanski; Andrzej Budzynski; Jerzy Stachura Journal: Dig Dis Sci Date: 2005-03 Impact factor: 3.199