AIM: To identify and describe electron microscopic changes occurring in Enterocytozoon bieneusi in patients treated with albendazole. METHODS: Eighteen HIV seropositive patients with E bieneusi infection of the small intestine were treated with albendazole 400 mg twice a day for one month. Duodenal biopsy specimens obtained before and at the end of treatment were examined electron microscopically by a pathologist who was unaware of the clinical response. A semiquantitative assessment of the parasite load and description of the parasite morphology was made. RESULTS: A complete resolution of diarrhoea occurred in nine patients and a further three had a greater than 50% reduction in baseline stool frequency or volume. Three of the non-responders were also infected with cryptosporidium. There was a reduction in parasite load in those responding to treatment and an increase in abnormal forms in both responders and non-responders. CONCLUSION: The clinical response to albendazole treatment seen in some patients with small intestine microsporidiosis may be due to damage to the developmental stages, causing a partial inhibition of parasite reproduction.
AIM: To identify and describe electron microscopic changes occurring in Enterocytozoon bieneusi in patients treated with albendazole. METHODS: Eighteen HIV seropositivepatients with E bieneusi infection of the small intestine were treated with albendazole 400 mg twice a day for one month. Duodenal biopsy specimens obtained before and at the end of treatment were examined electron microscopically by a pathologist who was unaware of the clinical response. A semiquantitative assessment of the parasite load and description of the parasite morphology was made. RESULTS: A complete resolution of diarrhoea occurred in nine patients and a further three had a greater than 50% reduction in baseline stool frequency or volume. Three of the non-responders were also infected with cryptosporidium. There was a reduction in parasite load in those responding to treatment and an increase in abnormal forms in both responders and non-responders. CONCLUSION: The clinical response to albendazole treatment seen in some patients with small intestine microsporidiosis may be due to damage to the developmental stages, causing a partial inhibition of parasite reproduction.
Authors: L Beaugerie; M F Teilhac; A M Deluol; J Fritsch; P M Girard; W Rozenbaum; Y Le Quintrec; F P Chatelet Journal: Ann Intern Med Date: 1992-09-01 Impact factor: 25.391
Authors: S Di Rosa; M Affronti; R Malta; M Scardavi; L Vassallo; C Occhino; A Maggio; F Savalli; G B Rini Journal: J Chemother Date: 1989-07 Impact factor: 1.714
Authors: J K Eeftinck Schattenkerk; T van Gool; R J van Ketel; J F Bartelsman; C L Kuiken; W J Terpstra; P Reiss Journal: Lancet Date: 1991-04-13 Impact factor: 79.321
Authors: D Dionisio; L I Manneschi; S Di Lollo; A Orsi; G Sterrantino; M Meli; M Gabbrielli; A Tani; A Papucci; F Leoncini Journal: J Clin Pathol Date: 1997-06 Impact factor: 3.411
Authors: D Dionisio; L I Manneschi; S Di Lollo; A Orsi; G Sterrantino; F Leoncini; M Pozzi; M A Vinattieri; A Tani; A Papucci Journal: J Clin Pathol Date: 1998-10 Impact factor: 3.411