Literature DB >> 822448

Influence of thyrotropin releasing hormone (TRH) on drug-induced narcosis and hypothermia in rabbits.

A Horita, M A Carino, R M Chesnut.   

Abstract

Thyrotropin releasing hormone (TRH) administered via the intracerebroventricular (icv) route in doses ranging between 0.1 and 100 mug decreased the duration of pentobarbital-induced narcosis in rabbits. Antagonism of narcosis occurred whether TRH was administered before or after the barbiturate. TRH doses above 10 mug produced, in addition, behavioral excitation and hyperthermia. The antagonism of phenobarbital-induced narcosis was not as profound; animals were aroused only for a short period of time, after which the narcotized state returned. However, TRH exerted a prolonged antagonism or reversal of the phenobarbital-induced hypothermia. The central nervous system depression and analgesia produced by morphine were unaffected by TRH, but hypothermia and respiratory depression were reversed. TRH may represent an arousal factor in mammalian brain.

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Year:  1976        PMID： 822448     DOI： 10.1007/BF00427471

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  11 in total

1.  Thyrotropin releasing hormone (TRH): apparent receptor binding in rat brain membranes.

Authors:  D R Burt; S H Snyder
Journal:  Brain Res       Date:  1975-08-08       Impact factor: 3.252

2.  Inhibition of (+)-amphetamine hyperthermia by blockade of dopamine receptors in rabbits.

Authors:  H F Hill; A Horita
Journal:  J Pharm Pharmacol       Date:  1971-09       Impact factor: 3.765

3.  Actions of 5-hydroxytryptamine and 5-hydroxytryptophan injected by various routes on the rectal temperature of the rabbit.

Authors:  J Jacob; J M Girault; R Peindaries
Journal:  Neuropharmacology       Date:  1972-01       Impact factor: 5.250

4.  Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone.

Authors:  A J Kastin; R H Ehrensing; D S Schalch; M S Anderson
Journal:  Lancet       Date:  1972-10-07       Impact factor: 79.321

5.  Effects of thyrotropin releasing hormone (TRH, microinjected into various areas of conscious and pentobarbital-pretreated rabbits.

Authors:  A Horita; M A Carino; B G Weick
Journal:  Proc West Pharmacol Soc       Date:  1976

6.  Thydrotropin releasing hormone: antagonism of pentobarbital in rodents.

Authors:  A J Prange; G R Breese; J M Cott; B R Martin; B R Cooper; I C Wilson; N P Plotnikoff
Journal:  Life Sci       Date:  1974-02-01       Impact factor: 5.037

7.  Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone.

Authors:  N P Plotnikoff; A J Prange; G R Breese; M S Anderson; I C Wilson
Journal:  Science       Date:  1972-10-27       Impact factor: 47.728

8.  Thyrotropin-releasing hormone (TRH)-induced hyperthermia and behavioral excitation in rabbits.

Authors:  A Horita; M A Carino
Journal:  Psychopharmacol Commun       Date:  1975

9.  Central nervous system effects of hypothalamic peptides.

Authors:  M Brown; W Vale
Journal:  Endocrinology       Date:  1975-05       Impact factor: 4.736

10.  Thyrotropin-releasing hormone: regional distribution in rat brain.

Authors:  A Winokur; R D Utiger
Journal:  Science       Date:  1974-07-19       Impact factor: 47.728
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  10 in total

1.  Effect of injection of TRH into cerebral ventricles on the analgesic effect of acupuncture and morphine in rats.

Authors:  Z D Zhang; Z P Tu
Journal:  J Tongji Med Univ       Date:  1986

Review 2.  Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?

Authors:  Marieke Hyke Algera; Joseph F Cotten; Monique van Velzen; Marieke Niesters; Martijn Boon; Daniel S Shoham; Kaye E Dandrea; Rutger van der Schrier; Albert Dahan
Journal:  Pharmacol Res Perspect       Date:  2022-06

3.  An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function.

Authors:  G D Frye; G R Breese; R B Mailman; R A Vogel; M G Ondrusek; R A Mueller
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

4.  The effects of TRH analogues on cerebral ischaemia produced by middle cerebral artery occlusion in the rat.

Authors:  J Shrewsbury-Gee; R H Lye; A Latham; P Slater
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

5.  Intravenous thyrotropin releasing hormone (TRH) enhances the excitatory actions of acetylcholine (ACh) on rat cortical neurons.

Authors:  G G Yarbrough; D K Singh
Journal:  Experientia       Date:  1978-03-15

6.  The effect of highly selective inhibitors of the uptake of noradrenaline or 5-hydroxytryptamine on TRH-induced hyperthermia in mice.

Authors:  L Pawłowski; H Kwiatek
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

7.  Potentiation by TRH of the effect of imipramine on the forced-swimming test.

Authors:  V Reny-Palasse; R Rips
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

8.  Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome.

Authors:  H N Bhargava; G A Matwyshyn
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

9.  The effects of thyrotropin-releasing hormone on the central nervous system responses to chronic morphine administration.

Authors:  H N Bhargava
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

10.  D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats.

Authors:  Olivia A Moody; Edlyn R Zhang; Vipin Arora; Risako Kato; Joseph F Cotten; Ken Solt
Journal:  Front Pharmacol       Date:  2020-11-12       Impact factor: 5.810
  10 in total

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