| Literature DB >> 8224211 |
M Ramani1, V Ollivier, F Khechai, T Vu, C Ternisien, F Bridey, D de Prost.
Abstract
In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.Entities:
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Year: 1993 PMID： 8224211 DOI： 10.1016/0014-5793(93)81693-t
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124