Literature DB >> 8223953

Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils.

I Just1, M Wille, C Chaponnier, K Aktories.   

Abstract

The gelsolin-actin complex was ADP-ribosylated by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin in lysates of human platelets and human neutrophils. When [32P]orthophosphate-labelled human neutrophils were treated with C. botulinum C2 toxin, [32P]ADP-ribosylated gelsolin-actin was precipitated with anti-gelsolin antibody. Stimulation of neutrophils by formyl-methionine-leucine-phenylalanine decreased the interaction of gelsolin with ADP-ribosylated actin in toxin-treated cells. The data indicate that the gelsolin-actin complex is a pathophysiological substrate for actin-ADP-ribosylating toxins.

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Year:  1993        PMID： 8223953     DOI： 10.1016/0922-4106(93)90045-b

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

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Authors:  G Kiefer; M Lerner; P Sehr; I Just; K Aktories
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Review 5.  Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.

Authors:  K Aktories
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6.  ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death.

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Review 7.  Clostridium and bacillus binary enterotoxins: bad for the bowels, and eukaryotic being.

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  7 in total

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