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Literature DB >> 7898461

Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.

Abstract

The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years. Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization. Clostridium botulinum exoenzyme C3 and Clostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of the actin cytoskeleton. ADP-ribosylation inactivates the regulatory Rho proteins and disturbs the organization of the actin cytoskeleton.

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Year: 1994 PMID： 7898461 DOI： 10.1007/bf00928459

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

114 in total

1. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

Authors: A J Ridley; A Hall
Journal: Cell Date: 1992-08-07 Impact factor: 41.582

2. Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis.

Authors: M Sugai; K Hashimoto; A Kikuchi; S Inoue; H Okumura; K Matsumoto; Y Goto; H Ohgai; K Moriishi; B Syuto
Journal: J Biol Chem Date: 1992-02-05 Impact factor: 5.157

3. Mono-ADP-ribosylation in brain: purification and characterization of ADP-ribosyltransferases affecting actin from rat brain.

Authors: S Matsuyama; S Tsuyama
Journal: J Neurochem Date: 1991-10 Impact factor: 5.372

Review 4. Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins.

Authors: K Aktories; A Hall
Journal: Trends Pharmacol Sci Date: 1989-10 Impact factor: 14.819

5. Plasma gelsolin caps and severs actin filaments.

Authors: H E Harris; A G Weeds
Journal: FEBS Lett Date: 1984-11-19 Impact factor: 4.124

6. Response of mouse intestinal loop to botulinum C2 toxin: enterotoxic activity induced by cooperation of nonlinked protein components.

Authors: I Ohishi
Journal: Infect Immun Date: 1983-05 Impact factor: 3.441

7. Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

Authors: W Wiegers; I Just; H Müller; A Hellwig; P Traub; K Aktories
Journal: Eur J Cell Biol Date: 1991-04 Impact factor: 4.492

Review 8. ADP-ribosylation of actin by clostridial toxins.

Authors: K Aktories; A Wegner
Journal: J Cell Biol Date: 1989-10 Impact factor: 10.539

9. Influence of botulinum C2 toxin on F-actin and N-formyl peptide receptor dynamics in human neutrophils.

Authors: J Norgauer; I Just; K Aktories; L A Sklar
Journal: J Cell Biol Date: 1989-09 Impact factor: 10.539

10. Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148.

Authors: S F Carroll; J A McCloskey; P F Crain; N J Oppenheimer; T M Marschner; R J Collier
Journal: Proc Natl Acad Sci U S A Date: 1985-11 Impact factor: 12.779

6 in total

1. Characterization of the enzymatic component of Clostridium perfringens iota-toxin.

Authors: M Nagahama; Y Sakaguchi; K Kobayashi; S Ochi; J Sakurai
Journal: J Bacteriol Date: 2000-04 Impact factor: 3.490

2. Apically exposed, tight junction-associated beta1-integrins allow binding and YopE-mediated perturbation of epithelial barriers by wild-type Yersinia bacteria.

Authors: F Tafazoli; A Holmström; A Forsberg; K E Magnusson
Journal: Infect Immun Date: 2000-09 Impact factor: 3.441