Literature DB >> 8223898

Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea.

A Trifilieff1, Y Amrani, Y Landry, J P Gies.   

Abstract

We investigated the effect of two new bradykinin receptor antagonists, D-Arg0[Hyp3,D-HypE(trans-propyl)7,Oic8]bradykinin (NPC 17731) and D-Arg0[Hyp3,D-HypE(trans-thiophenyl)7,Oic8]bradykinin (NPC 17761) on [3H]bradykinin binding and on bradykinin-induced contraction of the guinea-pig trachea. Both of these compounds inhibited [3H]bradykinin binding with an affinity similar to that of unlabelled bradykinin. NPC 17731 inhibited bradykinin-induced contraction in a non-competitive manner, whereas NPC 17761 showed competitive antagonism. Therefore, NPC 17761 could contribute to the investigation of the bradykinin receptors in guinea-pig airways.

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Year:  1993        PMID： 8223898     DOI： 10.1016/0014-2999(93)91000-d

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.

Authors:  J W Dear; K Wirth; G K Scadding; J C Foreman
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

2.  Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea.

Authors:  D Scherrer; L Daeffler; A Trifilieff; J P Gies
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

3.  Biphasic increase in cytosolic free calcium induced by bradykinin and histamine in cultured tracheal smooth muscle cells: is the sustained phase artifactual?

Authors:  Y Amrani; A Da Silva; O Kassel; C Bronner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000

4.  Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea.

Authors:  A Da Silva; Y Amrani; A Trifilieff; Y Landry
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

5.  Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform.

Authors:  Y Amrani; C Magnier; J Enouf; F Wuytack; C Bronner
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

6.  Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens.

Authors:  J Maas; G A Rae; J P Huidobro-Toro; J B Calixto
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

7.  Effects of a novel nonpeptide bradykinin B2 receptor antagonist on intestinal and airway smooth muscle: further evidence for the tracheal B3 receptor.

Authors:  S G Farmer; M A DeSiato
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739
  7 in total

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