Literature DB >> 7582533

Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea.

D Scherrer1, L Daeffler, A Trifilieff, J P Gies.   

Abstract

We investigated the effect of the nonpeptide bradykinin receptor antagonist, [[4-[[2-[[bis(cyclohexylamino)methylene] amino]-3-(2-naphthalenyl) 1-oxopropyl]amino]-phenyl]-tributyl, chloride, monohydrochloride (WIN 64338), on [3H]-bradykinin binding and on bradykinin-induced contraction of the guinea-pig trachea. This non peptide bradykinin receptor antagonist inhibited [3H]-bradykinin binding with a nanomolar range of affinity, Ki = 50.9 +/- 19 nM and inhibited bradykinin-induced contraction in a non-competitive manner with a KB value of 6.43 10(-8) +/- 2.34 10(-8) M.

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Year:  1995        PMID： 7582533      PMCID： PMC1908803          DOI： 10.1111/j.1476-5381.1995.tb15013.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides.

Authors:  D J Kyle; J A Martin; R M Burch; J P Carter; S F Lu; S Meeker; J C Prosser; J P Sullivan; J Togo; L Noronha-Blob
Journal:  J Med Chem       Date:  1991-08       Impact factor: 7.446

2.  Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor.

Authors:  J M Salvino; P R Seoane; B D Douty; M M Awad; R E Dolle; W T Houck; D M Faunce; D G Sawutz
Journal:  J Med Chem       Date:  1993-08-20       Impact factor: 7.446

3.  Effect of Hoe 140, a new B2 noncompetitive antagonist, on guinea pig tracheal bradykinin receptors.

Authors:  A Trifilieff; A Da Silva; Y Landry; J P Gies
Journal:  J Pharmacol Exp Ther       Date:  1992-12       Impact factor: 4.030

4.  Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea.

Authors:  A Trifilieff; Y Amrani; Y Landry; J P Gies
Journal:  Eur J Pharmacol       Date:  1993-08-03       Impact factor: 4.432

5.  Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.

Authors:  K Wirth; F J Hock; U Albus; W Linz; H G Alpermann; H Anagnostopoulos; S Henk; G Breipohl; W König; J Knolle
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

6.  Effects of a novel nonpeptide bradykinin B2 receptor antagonist on intestinal and airway smooth muscle: further evidence for the tracheal B3 receptor.

Authors:  S G Farmer; M A DeSiato
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739

7.  Competitive antagonists of bradykinin.

Authors:  R J Vavrek; J M Stewart
Journal:  Peptides       Date:  1985 Mar-Apr       Impact factor: 3.750
  7 in total
  3 in total

1.  Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.

Authors:  J W Dear; K Wirth; G K Scadding; J C Foreman
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

2.  Bradykinin increases Na(+)-K(+) pump activity in cultured guinea-pig tracheal smooth muscle cells.

Authors:  A M Dodson; K J Rhoden
Journal:  Br J Pharmacol       Date:  2001-08       Impact factor: 8.739

Review 3.  A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases.

Authors:  Devasahayam Arokiar Balaya Rex; Neelanchal Vaid; K Deepak; Shobha Dagamajalu; T S Keshava Prasad
Journal:  Mol Biol Rep       Date:  2022-05-21       Impact factor: 2.742
  3 in total

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