| Literature DB >> 8222907 |
Y H Liu1, M X Qian, X G Wang, Y Z Quan, S H Yan, B Y Chen, J S Li, Z Y Qiu.
Abstract
Levo-praziquantel is the left isomer of racemic praziquantel. Animal experiments showed that it is an active component of schistosomicidal activity, while dextro-praziquantel is almost ineffective. Clinical trials in three endemic areas of Schistosomiasis japonica indicated that the therapeutic efficacy of levo-praziquantel is superior to racemic praziquantel. Pharmacokinetic and pharmacodynamic activities of the stereoselectivity of praziquantel isomers (enantiomers) are discussed.Entities:
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Year: 1993 PMID： 8222907
Source DB: PubMed Journal: Chin Med J (Engl) ISSN： 0366-6999 Impact factor: 2.628