OBJECTIVE: To treat diastolic dysfunction in patients with coronary artery disease (CAD). DESIGN: Open study of the intravenous injection of 5 mL of a solution containing 17% magnesium chloride (equal to 100 mg of elemental magnesium) during routine coronary angiography in patients with a raised left ventricular end-diastolic pressure (LVEDP). SETTING: A hospital department of cardiac hemodynamics. SUBJECTS: Ten patients with angiographically documented CAD. RESULTS: After magnesium chloride injection, the LVEDP was significantly reduced in all patients, from a mean of 24 +/- 3 to 16 +/- 3 mmHg (P < 0.001). CONCLUSIONS: Under the short term conditions of the study, the injection of magnesium chloride effectively improved left ventricular diastolic function. Further study of the long term effect is required.
OBJECTIVE: To treat diastolic dysfunction in patients with coronary artery disease (CAD). DESIGN: Open study of the intravenous injection of 5 mL of a solution containing 17% magnesium chloride (equal to 100 mg of elemental magnesium) during routine coronary angiography in patients with a raised left ventricular end-diastolic pressure (LVEDP). SETTING: A hospital department of cardiac hemodynamics. SUBJECTS: Ten patients with angiographically documented CAD. RESULTS: After magnesium chloride injection, the LVEDP was significantly reduced in all patients, from a mean of 24 +/- 3 to 16 +/- 3 mmHg (P < 0.001). CONCLUSIONS: Under the short term conditions of the study, the injection of magnesium chloride effectively improved left ventricular diastolic function. Further study of the long term effect is required.
Authors: Wen-Chih Wu; Mengna Huang; Tracey H Taveira; Mary B Roberts; Lisa W Martin; Gregory A Wellenius; Karen C Johnson; JoAnn E Manson; Simin Liu; Charles B Eaton Journal: J Am Heart Assoc Date: 2020-03-20 Impact factor: 5.501