Literature DB >> 821680

Pharmacological approaches to treating the obese patient.

G A Bray, F L Greenway.   

Abstract

It should be obvious from the foregoing discussion that, at the present time, there is not an acceptably safe and effective pharmacological treatment for obesity. This patent inadequacy of present drug regimens has spawned the investigation into the diverse pharmacological approaches reviewed in this paper as well as investigation into the intestinal bypass operation (see Chapter 10). We feel that the eventual, safe and effective therapy for obesity will come from the pharmacological realm. Glucose-blocking drugs, growth hormone analogues, and hydroxycitrate are but three of the potentially safe and effective approaches to the problem for the future. It will be truly fascinating to watch the development in the treatment of obesity and, specifically, the pharmacological treatment for this problem over the next five to ten years.

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Year:  1976        PMID: 821680     DOI: 10.1016/s0300-595x(76)80031-x

Source DB:  PubMed          Journal:  Clin Endocrinol Metab        ISSN: 0300-595X


  6 in total

Review 1.  Safety of drug therapies used for weight loss and treatment of obesity.

Authors:  Lisa L Ioannides-Demos; Joseph Proietto; Andrew M Tonkin; John J McNeil
Journal:  Drug Saf       Date:  2006       Impact factor: 5.606

2.  Adolescent nutrition: 3. Obesity. Nutrition Committee, Canadian Paediatric Society.

Authors: 
Journal:  Can Med Assoc J       Date:  1983-09-15       Impact factor: 8.262

3.  Human chorionic gonadotropin (HCG) in the treatment of obesity: a critical assessment of the Simeons method.

Authors:  F L Greenway; G A Bray
Journal:  West J Med       Date:  1977-12

4.  ATP-citrate lyase deficiency in the mouse.

Authors:  Anne P Beigneux; Cynthia Kosinski; Bryant Gavino; Jay D Horton; William C Skarnes; Stephen G Young
Journal:  J Biol Chem       Date:  2003-12-08       Impact factor: 5.157

5.  Further evidence for the presence of thyroxine binding globulin-like protein in human breast adipose tissue. Deiodination of thyroxine and triiodothyronine by the microsomal fraction.

Authors:  G S Rao; M L Rao; H D Quednau; W Greil
Journal:  J Endocrinol Invest       Date:  1985-12       Impact factor: 4.256

6.  Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Authors:  Christoffer Clemmensen; Sigrid Jall; Maximilian Kleinert; Carmelo Quarta; Tim Gruber; Josefine Reber; Stephan Sachs; Katrin Fischer; Annette Feuchtinger; Angelos Karlas; Stephanie E Simonds; Gerald Grandl; Daniela Loher; Eva Sanchez-Quant; Susanne Keipert; Martin Jastroch; Susanna M Hofmann; Emmani B M Nascimento; Patrick Schrauwen; Vasilis Ntziachristos; Michael A Cowley; Brian Finan; Timo D Müller; Matthias H Tschöp
Journal:  Nat Commun       Date:  2018-10-23       Impact factor: 14.919

  6 in total

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