OBJECTIVE: To evaluate the relationship of corpus callosum atrophy to cerebral cortical oxygen metabolism and cognitive function in patients with Alzheimer's disease. DESIGN: Prospective clinicoradiologic correlation with magnetic resonance imaging and positron emission tomography. SETTING: A university hospital. PATIENTS, PARTICIPANTS: Ten right-handed male patients with Alzheimer's disease, aged 46 to 70 years (mean +/- SD 57 +/- 6 years), and 14 age- and sex-matched right-handed control subjects. MAIN OUTCOME MEASURES: The midsagittal corpus callosum areas (on T1-weighted magnetic resonance images), cerebral metabolic rate of oxygen (measured with positron emission tomography using the oxygen-15 steady-state technique), and the IQs of the Wechsler Adult Intelligence Scale. RESULTS: Compared with control subjects, the patients had significantly decreased callosal areas with a posterior predominance of the degree of atrophy. The area of anterior and posterior halves of the corpus callosum had a significant correlation with the value of oxygen metabolism in the frontal and parietotemporo-occipital association cortices, respectively. The total area of the corpus callosum was significantly related to the total and verbal IQs of the Wechsler Adult Intelligence Scale. CONCLUSION: Atrophy of corpus callosum reflects the severity and pattern of cortical damage associated with hypometabolism and cognitive impairment in Alzheimer's disease.
OBJECTIVE: To evaluate the relationship of corpus callosum atrophy to cerebral corticaloxygen metabolism and cognitive function in patients with Alzheimer's disease. DESIGN: Prospective clinicoradiologic correlation with magnetic resonance imaging and positron emission tomography. SETTING: A university hospital. PATIENTS, PARTICIPANTS: Ten right-handed male patients with Alzheimer's disease, aged 46 to 70 years (mean +/- SD 57 +/- 6 years), and 14 age- and sex-matched right-handed control subjects. MAIN OUTCOME MEASURES: The midsagittal corpus callosum areas (on T1-weighted magnetic resonance images), cerebral metabolic rate of oxygen (measured with positron emission tomography using the oxygen-15 steady-state technique), and the IQs of the Wechsler Adult Intelligence Scale. RESULTS: Compared with control subjects, the patients had significantly decreased callosal areas with a posterior predominance of the degree of atrophy. The area of anterior and posterior halves of the corpus callosum had a significant correlation with the value of oxygen metabolism in the frontal and parietotemporo-occipital association cortices, respectively. The total area of the corpus callosum was significantly related to the total and verbal IQs of the Wechsler Adult Intelligence Scale. CONCLUSION:Atrophy of corpus callosum reflects the severity and pattern of cortical damage associated with hypometabolism and cognitive impairment in Alzheimer's disease.
Authors: H Yamauchi; H Fukuyama; Y Nagahama; Y Katsumi; T Hayashi; C Oyanagi; J Konishi; H Shio Journal: J Neurol Neurosurg Psychiatry Date: 2000-11 Impact factor: 10.154
Authors: Maurizio Bergamino; Elizabeth G Keeling; Leslie C Baxter; Nicholas J Sisco; Ryan R Walsh; Ashley M Stokes Journal: J Alzheimers Dis Date: 2022 Impact factor: 4.160