BACKGROUND: Measurement of regional atrophy of the corpus callosum and cortical grey matter may differentiate between primary loss of intracortical projecting neurons and primary fibre degeneration in Alzheimer's disease (AD) and vascular dementia (VD). METHODS: The regional corpus callosum area and cortical grey matter volumes were measured in 30 patients with the clinical diagnosis of probable AD, 20 patients with the clinical diagnosis of probable VD and 24 healthy elderly control subjects using MRI in two centers in Munich and Amsterdam. RESULTS: Patients with AD showed significantly reduced volumes of cortical grey matter in all cerebral lobes and atrophy of anterior and posterior corpus callosum areas. In VD patients only occipital lobe grey matter volume and anterior corpus callosum area were significantly reduced. In AD patients reduction of cortical grey matter volumes was significantly correlated with regional reductions of corpus callosum areas, but not in VD patients or controls. CONCLUSION: These findings support the notion that measurement of the corpus callosum and cortical grey matter atrophy may identify the underlying causes of cortical disconnection in AD and VD and may be helpful to differentiate between both conditions.
BACKGROUND: Measurement of regional atrophy of the corpus callosum and cortical grey matter may differentiate between primary loss of intracortical projecting neurons and primary fibre degeneration in Alzheimer's disease (AD) and vascular dementia (VD). METHODS: The regional corpus callosum area and cortical grey matter volumes were measured in 30 patients with the clinical diagnosis of probable AD, 20 patients with the clinical diagnosis of probable VD and 24 healthy elderly control subjects using MRI in two centers in Munich and Amsterdam. RESULTS:Patients with AD showed significantly reduced volumes of cortical grey matter in all cerebral lobes and atrophy of anterior and posterior corpus callosum areas. In VD patients only occipital lobe grey matter volume and anterior corpus callosum area were significantly reduced. In ADpatients reduction of cortical grey matter volumes was significantly correlated with regional reductions of corpus callosum areas, but not in VD patients or controls. CONCLUSION: These findings support the notion that measurement of the corpus callosum and cortical grey matter atrophy may identify the underlying causes of cortical disconnection in AD and VD and may be helpful to differentiate between both conditions.
Authors: D Mungas; W J Jagust; B R Reed; J H Kramer; M W Weiner; N Schuff; D Norman; W J Mack; L Willis; H C Chui Journal: Neurology Date: 2001-12-26 Impact factor: 9.910
Authors: A Brunetti; A Postiglione; E Tedeschi; A Ciarmiello; M Quarantelli; E M Covelli; G Milan; M Larobina; A Soricelli; A Sodano; B Alfano Journal: J Magn Reson Imaging Date: 2000-03 Impact factor: 4.813
Authors: S J Teipel; H Hampel; P Pietrini; G E Alexander; B Horwitz; E Daley; H J Möller; M B Schapiro; S I Rapoport Journal: Arch Neurol Date: 1999-04
Authors: K Nagata; H Maruya; H Yuya; H Terashi; Y Mito; H Kato; M Sato; Y Satoh; Y Watahiki; Y Hirata; E Yokoyama; J Hatazawa Journal: Ann N Y Acad Sci Date: 2000-04 Impact factor: 5.691
Authors: J Pantel; J Schröder; M Jauss; M Essig; R Minakaran; P Schönknecht; G Schneider; L R Schad; M V Knopp Journal: Psychiatry Res Date: 1999-06-30 Impact factor: 3.222
Authors: Henry Rusinek; Susan De Santi; Dina Frid; Wai-Hon Tsui; Chaim Y Tarshish; Antonio Convit; Mony J de Leon Journal: Radiology Date: 2003-12 Impact factor: 11.105
Authors: G C Román; T K Tatemichi; T Erkinjuntti; J L Cummings; J C Masdeu; J H Garcia; L Amaducci; J M Orgogozo; A Brun; A Hofman Journal: Neurology Date: 1993-02 Impact factor: 9.910
Authors: Jacqueline Hoeppner; Martin Wegrzyn; Johannes Thome; Alexandra Bauer; Imke Oltmann; Johannes Buchmann; Stefan Teipel Journal: J Neural Transm (Vienna) Date: 2011-11-13 Impact factor: 3.575