OBJECTIVES: To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS: A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS: Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. CONCLUSIONS: Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study.
OBJECTIVES: To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS: A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS: Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. CONCLUSIONS: Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study.
Authors: F C Arnett; S M Edworthy; D A Bloch; D J McShane; J F Fries; N S Cooper; L A Healey; S R Kaplan; M H Liang; H S Luthra Journal: Arthritis Rheum Date: 1988-03
Authors: E Scotet; J David-Ameline; M A Peyrat; A Moreau-Aubry; D Pinczon; A Lim; J Even; G Semana; J M Berthelot; R Breathnach; M Bonneville; E Houssaint Journal: J Exp Med Date: 1996-11-01 Impact factor: 14.307
Authors: L C Tan; A G Mowat; C Fazou; T Rostron; H Roskell; P R Dunbar; C Tournay; F Romagné; M A Peyrat; E Houssaint; M Bonneville; A B Rickinson; A J McMichael; M F Callan Journal: Arthritis Res Date: 2000-02-07