Literature DB >> 8215291

Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia.

R R Tidwell1, S K Jones, N A Naiman, L C Berger, W B Brake, C C Dykstra, J E Hall.   

Abstract

On the basis of a previously observed correlation between the antimicrobial activity and DNA binding strength of dicationic molecules, a series of 10 dicationically substituted bis-benzimidazoles were tested for activity in the rat model of Pneumocystis carinii pneumonia. One of the compounds, 1,4-bis[5-(2-imidazolinyl)-2-benzimidazolyl]butane, was found to be more potent and less toxic than pentamidine.

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Year:  1993        PMID： 8215291      PMCID： PMC188050          DOI： 10.1128/AAC.37.8.1713

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  [A new method of treating interstitial plasma cell pneumonia in premature infant with 5-valent antimony & aromatic diamidines].

Authors:  G IVADY; L PALDY
Journal:  Monatsschr Kinderheilkd       Date:  1958-01

2.  Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine.

Authors:  J A Golden; D Chernoff; H Hollander; D Feigal; J E Conte
Journal:  Lancet       Date:  1989-03-25       Impact factor: 79.321

3.  Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

Authors:  R R Tidwell; S K Jones; J D Geratz; K A Ohemeng; M Cory; J E Hall
Journal:  J Med Chem       Date:  1990-04       Impact factor: 7.446

4.  A rapid staining procedure for Pneumocystis carinii.

Authors:  M C Bowling; I M Smith; S L Wescott
Journal:  Am J Med Technol       Date:  1973-07

Review 5.  Present status of chemotherapy and chemopropylaxis of human trypanosomiasis in the Eastern Hemisphere.

Authors:  F I Apted
Journal:  Pharmacol Ther       Date:  1980       Impact factor: 12.310

6.  Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.

Authors:  C A Bell; J E Hall; D E Kyle; M Grogl; K A Ohemeng; M A Allen; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1990-07       Impact factor: 5.191

7.  Visceral leishmaniasis unresponsive to antimonial drugs. II. Response to high dosage sodium stibogluconate or prolonged treatment with pentamidine.

Authors:  A D Bryceson; J D Chulay; M Mugambi; J B Were; G Gachihi; C N Chunge; R Muigai; S M Bhatt; M Ho; H C Spencer
Journal:  Trans R Soc Trop Med Hyg       Date:  1985       Impact factor: 2.184

8.  New aromatic diamidines with central alpha-oxyalkane or alpha, omega-dioxyalkane chains. Structure-activity relationships for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation process.

Authors:  J D Geratz; M C Cheng; R R Tidwell
Journal:  J Med Chem       Date:  1975-05       Impact factor: 7.446

9.  Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

Authors:  P D Walzer; C K Kim; J Foy; M J Linke; M T Cushion
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

10.  Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.

Authors:  R R Tidwell; J D Geratz; O Dann; G Volz; D Zeh; H Loewe
Journal:  J Med Chem       Date:  1978-07       Impact factor: 7.446
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  22 in total

1.  Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).

Authors:  E Gavathiotis; G J Sharman; M S Searle
Journal:  Nucleic Acids Res       Date:  2000-02-01       Impact factor: 16.971

2.  Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.

Authors:  A Kumar; D Boykin; W Wilson; S Jones; B Bender; C Dykstra; J Hall; R Tidwell
Journal:  Eur J Med Chem       Date:  1996       Impact factor: 6.514

3.  Synthesis of dicationic diarylpyridines as nucleic-acid binding agents.

Authors:  A Kumar; Ra Rhodes; J Spychala; Wd Wilson; Dw Boykin; Rr Tidwell; Cc Dykstra; Je Hall; Sk Jones; Rf Schinazi
Journal:  Eur J Med Chem       Date:  1995       Impact factor: 6.514

4.  The synthesis of dicationic extended bis-benzimidazoles.

Authors:  Zhijan Kang; Christine C Dykstra; David W Boykin
Journal:  Molecules       Date:  2004-02-28       Impact factor: 4.411

Review 5.  Treatment of infection due to Pneumocystis carinii.

Authors:  J A Fishman
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191

6.  Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use.

Authors:  H M Reisner; D R Gray; S K Jones; B G Rose; R R Tidwell
Journal:  J Clin Lab Anal       Date:  2000       Impact factor: 2.352

7.  Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations.

Authors:  C E Bostock-Smith; S A Harris; C A Laughton; M A Searle
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971

8.  Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats.

Authors:  P D Walzer; J Foy; J Runck; P Steele; M White; R S Klein; B A Otter; R J Sundberg
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

9.  Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition.

Authors:  C A Bell; C C Dykstra; N A Naiman; M Cory; T A Fairley; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

10.  (E)-1,1'-Bis[(E)-but-2-en-yl]-3,3'-(propane-1,3-di-yl)bis-(1H-benzimidazol-3-ium) dibromide monohydrate.

Authors:  Mehmet Akkurt; Sema Öztürk Yıldırım; Nihat Sireci; Hasan Küçükbay; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-18
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