Literature DB >> 821474

Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations.

C S Berry, M Caldecourt, T Hallinan.   

Abstract

Phospholipid depletion substantially inhibited the maximum demonstrable activities of the forward (glucuronidation) and reverse reactions of UDP-glucuronyltransferase towards p-nitrophenol in guinea-pig liver microsomal preparations. Dispersions of liver phospholipids restored activity, whereas non-phospholipid amphipaths failed to do so effectively. These results suggest that the system is probably phospholipid-dependent rather than conformationally constrained by phospholipids.

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Year:  1976        PMID： 821474      PMCID： PMC1172782          DOI： 10.1042/bj1540783

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Inhibition of glucose 6-phosphatase by pure and impure C-type phospholipases. Reactivation by phospholipid dispersions and protection by serum albumin.

Authors:  B R Cater; P Trivedi; T Hallinan
Journal:  Biochem J       Date:  1975-05       Impact factor: 3.857

2.  Regulation of microsomal enzymes by phospholipids. IV. Species differences in the properties of microsomal UDP-glucuronyltransferase.

Authors:  D A Vessey; D Zakim
Journal:  Biochim Biophys Acta       Date:  1972-04-07

3.  Studies on microsomal nucleoside diphosphatase of rat hepatocytes. Its purification, intramembranous localization, and turnover.

Authors:  Y Kuriyama
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

4.  Regulation of microsomal enzymes by phospholipids. II. Acitvation of hepatic uridine diphosphate-glucuronyltransferase.

Authors:  D A Vessey; D Zakim
Journal:  J Biol Chem       Date:  1971-08-10       Impact factor: 5.157

5.  Spontaneous and detergent activation of a glucuronyltransferase in vitro.

Authors:  K K Lueders; E L Kuff
Journal:  Arch Biochem Biophys       Date:  1967-04       Impact factor: 4.013

6.  Kinetic properties of different forms of hepatic UDPglucuronyltransferase.

Authors:  A Winsnes
Journal:  Biochim Biophys Acta       Date:  1972-10-12

7.  Studies on a solubilized oestriol 16 -glucuronyltransferase from human liver microsomes.

Authors:  G S Rao; M L Rao; H Breuer
Journal:  J Steroid Biochem       Date:  1972-01       Impact factor: 4.292

8.  Influence of membrane lipids on the regulatory properties of UDP-glucuronyltransferase.

Authors:  D Zakim; J Goldenberg; D A Vessey
Journal:  Eur J Biochem       Date:  1973-09-21

9.  Hydrolysis of erythrocyte membrane phospholipids by a preparation of phospholipase C from Clostridium Welchii. Deactivation of (Ca-2+, Mg-2+)-ATPase and its reactivation by added lipids.

Authors:  R Coleman; T A Bramley
Journal:  Biochim Biophys Acta       Date:  1975-04-08

10.  Regulation of microsomal enzymes by phospholipids. IX. Production of uniquely modified forms of microsomal UDP-glucuronyltransferase by treatment with phospholipase A and detergents.

Authors:  K Zakim; D A Vessey
Journal:  Biochim Biophys Acta       Date:  1975-11-20
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  6 in total

1.  Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities.

Authors:  R H Tukey; R E Billings; T R Tephly
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

2.  The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity (reverse reaction).

Authors:  J Cummings; A B Graham; G C Wood
Journal:  Biochem J       Date:  1980-02-01       Impact factor: 3.857

3.  Phospholipid content and activity of pure uridine diphosphate-glucuronyltransferase from rat liver.

Authors:  B Burchell; T Hallinan
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

4.  The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity and thermotropic changes in membrane structure.

Authors:  D T Pechey; A B Graham; G C Wood
Journal:  Biochem J       Date:  1978-10-01       Impact factor: 3.857

5.  Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase.

Authors:  R H Tukey; R E Billings; A P Autor; T R Tephly
Journal:  Biochem J       Date:  1979-04-01       Impact factor: 3.857

6.  The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Phospholipid depletion and re-activation of guinea-pig liver microsomal enzyme.

Authors:  A B Graham; D T Pechey; K C Toogood; S B Thomas; G C Wood
Journal:  Biochem J       Date:  1977-04-01       Impact factor: 3.857
  6 in total

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