Literature DB >> 8213350

Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats.

G W Cannon1, S McCall, B C Cole, L A Radov, J R Ward, M M Griffiths.   

Abstract

The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8213350     DOI： 10.1007/bf01976216

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  27 in total

1.  The effects of flurbiprofen on the passive transfer of adjuvant-induced arthritis.

Authors:  G W Cannon; D S Harper
Journal:  Agents Actions       Date:  1992-01

2.  Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

Authors:  D T Walz; M J DiMartino; L W Chakrin; B M Sutton; A MISHER
Journal:  J Pharmacol Exp Ther       Date:  1976-04       Impact factor: 4.030

3.  Effects of weekly and daily pretreatment with gold sodium thiomalate on adjuvant induced arthritis.

Authors:  G W Cannon; C B Smith; B C Cole; J R Ward
Journal:  J Rheumatol       Date:  1987-04       Impact factor: 4.666

4.  Anti-arthritic and immunoregulatory effects of TI-31 on collagen-induced arthritis.

Authors:  K Komoriya; I Nagata; K Kunisawa; T Takeshita; T Naruchi
Journal:  Jpn J Pharmacol       Date:  1987-11

5.  Immunogenetic control of experimental collagen-induced arthritis in rats. II. ECIA susceptibility and immune response to type II collagen (CALF) are linked to RT1.

Authors:  M M Griffiths; C W DeWitt
Journal:  J Immunogenet       Date:  1981-12

6.  Action of gold salts in some inflammatory and immunological models.

Authors:  A J Lewis; J Cottney; D D White; P K Fox; A McNeillie; J Dunlop; W E Smith; D H Brown
Journal:  Agents Actions       Date:  1980-04

7.  Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents.

Authors:  A E Sloboda; J E Birnbaum; A L Oronsky; S S Kerwar
Journal:  Arthritis Rheum       Date:  1981-04

8.  Effects of cyclosporin on collagen induced arthritis in mice.

Authors:  K Takagishi; N Kaibara; T Hotokebuchi; C Arita; M Morinaga; K Arai
Journal:  Ann Rheum Dis       Date:  1986-04       Impact factor: 19.103

9.  CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.

Authors:  B B NEWBOULD
Journal:  Br J Pharmacol Chemother       Date:  1963-08

10.  Comparison of inflammatory changes in established type II collagen- and adjuvant-induced arthritis using outbred Wistar rats.

Authors:  R P Carlson; L J Datko; L O'Neill-Davis; E M Blazek; F DeLustro; R Beideman; A J Lewis
Journal:  Int J Immunopharmacol       Date:  1985
View more
  3 in total

1.  Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-alpha) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats.

Authors:  K kerlund; H Erlandsson Harris; K J Tracey; H Wang; T Fehniger; L Klareskog; J Andersson; U Andersson
Journal:  Clin Exp Immunol       Date:  1999-01       Impact factor: 4.330

2.  Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A.

Authors:  L M Ayer; A C Issekutz; C C Waterhouse; A W Stadnyk
Journal:  Inflammation       Date:  2000-10       Impact factor: 4.092

3.  Effect of clodronate on established collagen-induced arthritis in rats.

Authors:  T Osterman; K Kippo; L Laurén; R Hannuniemi; R Sellman
Journal:  Inflamm Res       Date:  1995-06       Impact factor: 4.575
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.