Literature DB >> 8203866

Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy.

J A Bilello1, J L Eiseman, H C Standiford, G L Drusano.   

Abstract

We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 micrograms/h maintained levels > 1 microM in plasma and > 0.2 microM in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8203866      PMCID： PMC284511          DOI： 10.1128/AAC.38.3.628

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Human immunodeficiency virus in vacuolar myelopathy of the acquired immunodeficiency syndrome.

Authors:  H Budka; H Maier; P Pohl
Journal:  N Engl J Med       Date:  1988-12-22       Impact factor: 91.245

2.  "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

Authors:  W N Burnette
Journal:  Anal Biochem       Date:  1981-04       Impact factor: 3.365

3.  LAGRAN program for area and moments in pharmacokinetic analysis.

Authors:  M L Rocci; W J Jusko
Journal:  Comput Programs Biomed       Date:  1983-06

4.  Plaque assay techniques for murine leukemia viruses.

Authors:  W P Rowe; W E Pugh; J W Hartley
Journal:  Virology       Date:  1970-12       Impact factor: 3.616

5.  Characterization of a progressive neurodegenerative disease induced by a temperature-sensitive Moloney murine leukemia virus infection.

Authors:  J A Bilello; O M Pitts; P M Hoffman
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

6.  High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients.

Authors:  S Pang; Y Koyanagi; S Miles; C Wiley; H V Vinters; I S Chen
Journal:  Nature       Date:  1990-01-04       Impact factor: 49.962

7.  Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.

Authors:  D D Ho; T R Rota; R T Schooley; J C Kaplan; J D Allan; J E Groopman; L Resnick; D Felsenstein; C A Andrews; M S Hirsch
Journal:  N Engl J Med       Date:  1985-12-12       Impact factor: 91.245

8.  Efficacy of continuous zidovudine infusion at early stages of retroviral infection in mice.

Authors:  M Sinet; L Harcouet; B Desforges; J N Colin; R Farinotti; J J Pocidalo
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1992

9.  Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Authors:  P A Furman; J A Fyfe; M H St Clair; K Weinhold; J L Rideout; G A Freeman; S N Lehrman; D P Bolognesi; S Broder; H Mitsuya
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

10.  Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.

Authors:  H T Ho; M J Hitchcock
Journal:  Antimicrob Agents Chemother       Date:  1989-06       Impact factor: 5.938
View more
  4 in total

1.  Pharmacodynamics of fluconazole in a murine model of systemic candidiasis.

Authors:  A Louie; G L Drusano; P Banerjee; Q F Liu; W Liu; P Kaw; M Shayegani; H Taber; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

2.  Pharmacokinetics of zidovudine after rectal administration in human immunodeficiency virus-infected patients.

Authors:  U Wintergerst; B Rolinski; J R Bogner; G Notheis; F D Goebel; A A Roscher; B H Belohradsky
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

3.  Pharmacodynamics of daptomycin in a murine thigh model of Staphylococcus aureus infection.

Authors:  A Louie; P Kaw; W Liu; N Jumbe; M H Miller; G L Drusano
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

4.  Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents.

Authors:  Patricia M Flynn; John Rodman; Jane C Lindsey; Brian Robbins; Edmund Capparelli; Katherine M Knapp; Jose F Rodriguez; James McNamara; Leslie Serchuck; Barbara Heckman; Jaime Martinez
Journal:  Antimicrob Agents Chemother       Date:  2007-07-30       Impact factor: 5.191
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.