Literature DB >> 8202548

Dynamic instability of microtubules as an efficient way to search in space.

T E Holy1, S Leibler.   

Abstract

During the formation of the mitotic spindle, dynamic microtubules search for chromosomes in the surrounding cytosol. The average time required to reach such "targets" is calculated within a simple model of dynamic instability. The values of the dynamic parameters that minimize this search time are also obtained. The results approximate well observations of the capture of chromosomes in prometaphase cells. Compared to usual reversible polymerization, dynamic instability reduces the time required to find a target by several orders of magnitude.

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Year:  1994        PMID： 8202548      PMCID： PMC44060          DOI： 10.1073/pnas.91.12.5682

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

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Authors:  R F Gildersleeve; A R Cross; K E Cullen; A P Fagen; R C Williams
Journal:  J Biol Chem       Date:  1992-04-25       Impact factor: 5.157

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Authors:  U P Roos
Journal:  Chromosoma       Date:  1976-03-10       Impact factor: 4.316

Review 3.  Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability.

Authors:  T J Mitchison; M W Kirschner
Journal:  Cell Biophys       Date:  1987-12

4.  Mechanisms of regulating tubulin synthesis in cultured mammalian cells.

Authors:  A Ben-Ze'ev; S R Farmer; S Penman
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

Review 5.  Beyond self-assembly: from microtubules to morphogenesis.

Authors:  M Kirschner; T Mitchison
Journal:  Cell       Date:  1986-05-09       Impact factor: 41.582

6.  Unpolymerized tubulin modulates the level of tubulin mRNAs.

Authors:  D W Cleveland; M A Lopata; P Sherline; M W Kirschner
Journal:  Cell       Date:  1981-08       Impact factor: 41.582

7.  Dynamic instability of microtubule growth.

Authors:  T Mitchison; M Kirschner
Journal:  Nature       Date:  1984 Nov 15-21       Impact factor: 49.962

8.  Autoregulation of tubulin synthesis in enucleated cells.

Authors:  J M Caron; A L Jones; L B Rall; M W Kirschner
Journal:  Nature       Date:  1985 Oct 17-23       Impact factor: 49.962

9.  Real-time observations of microtubule dynamic instability in living cells.

Authors:  L Cassimeris; N K Pryer; E D Salmon
Journal:  J Cell Biol       Date:  1988-12       Impact factor: 10.539

10.  Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.

Authors:  F Verde; M Dogterom; E Stelzer; E Karsenti; S Leibler
Journal:  J Cell Biol       Date:  1992-09       Impact factor: 10.539
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  76 in total

1.  Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast.

Authors:  K R Anders; D Botstein
Journal:  Mol Biol Cell       Date:  2001-12       Impact factor: 4.138

2.  beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast.

Authors:  Mohan L Gupta; Claudia J Bode; Douglas A Thrower; Chad G Pearson; Kathy A Suprenant; Kerry S Bloom; Richard H Himes
Journal:  Mol Biol Cell       Date:  2002-08       Impact factor: 4.138

3.  Centrosome reorientation in wound-edge cells is cell type specific.

Authors:  Anne-Marie C Yvon; Jonathan W Walker; Barbara Danowski; Carey Fagerstrom; Alexey Khodjakov; Patricia Wadsworth
Journal:  Mol Biol Cell       Date:  2002-06       Impact factor: 4.138

4.  A force balance model of early spindle pole separation in Drosophila embryos.

Authors:  E N Cytrynbaum; J M Scholey; A Mogilner
Journal:  Biophys J       Date:  2003-02       Impact factor: 4.033

5.  Auxin deprivation induces a developmental switch in maize somatic embryogenesis involving redistribution of microtubules and actin filaments from endoplasmic to cortical cytoskeletal arrays.

Authors:  J Samaj; F Baluska; A Pretová; D Volkmann
Journal:  Plant Cell Rep       Date:  2003-04-03       Impact factor: 4.570

Review 6.  Biophysics of mitosis.

Authors:  J Richard McIntosh; Maxim I Molodtsov; Fazly I Ataullakhanov
Journal:  Q Rev Biophys       Date:  2012-02-10       Impact factor: 5.318

Review 7.  Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.

Authors:  P Silva; J Barbosa; A V Nascimento; J Faria; R Reis; H Bousbaa
Journal:  Cell Prolif       Date:  2011-10       Impact factor: 6.831

8.  Speed, dissipation, and error in kinetic proofreading.

Authors:  Arvind Murugan; David A Huse; Stanislas Leibler
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-11       Impact factor: 11.205

Review 9.  Cell mechanics and the cytoskeleton.

Authors:  Daniel A Fletcher; R Dyche Mullins
Journal:  Nature       Date:  2010-01-28       Impact factor: 49.962

Review 10.  Reaction-diffusion systems in intracellular molecular transport and control.

Authors:  Siowling Soh; Marta Byrska; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal:  Angew Chem Int Ed Engl       Date:  2010-06-07       Impact factor: 15.336
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