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Literature DB >> 8202483

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

L Hengst¹, V Dulic, J M Slingerland, E Lees, S I Reed.

Abstract

Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4.

Entities: Gene Species

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Year: 1994 PMID： 8202483 PMCID： PMC43980 DOI： 10.1073/pnas.91.12.5291

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

Review 1. The role of p34 kinases in the G1 to S-phase transition.

Authors: S I Reed
Journal: Annu Rev Cell Biol Date: 1992

Review 2. Dominoes and clocks: the union of two views of the cell cycle.

Authors: A W Murray; M W Kirschner
Journal: Science Date: 1989-11-03 Impact factor: 47.728

Review 3. Mitotic control.

Authors: J L Maller
Journal: Curr Opin Cell Biol Date: 1991-04 Impact factor: 8.382

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

Review 1. The role of p34 kinases in the G1 to S-phase transition.

Review 2. Dominoes and clocks: the union of two views of the cell cycle.

Review 3. Mitotic control.

4. An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae.

5. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

6. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

7. Association of human cyclin E with a periodic G1-S phase protein kinase.

8. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

9. Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

10. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1. The p27/Kip1 locus shows no loss of heterozygosity in human pituitary adenomas.

2. Circadian variation in the expression of cell-cycle proteins in human oral epithelium.

3. Overexpression of p27(KIP1) induced cell cycle arrest in G(1) phase and subsequent apoptosis in HCC-9204 cell line.

Review 4. Integration of the pRB and p53 cell cycle control pathways.

5. The CRM1 nuclear export protein in normal development and disease.

6. p27Kip1 inhibits the cell cycle through non-canonical G1/S phase-specific gatekeeper mechanism.

7. p27Kip1 acts downstream of N-cadherin-mediated cell adhesion to promote myogenesis beyond cell cycle regulation.

8. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.

9. Effect of p27(KIP1) on cell cycle and apoptosis in gastric cancer cells.

Review 10. p27 deregulation in breast cancer: prognostic significance and implications for therapy.