Literature DB >> 8202373

Mitochondrial transcripts are processed but are not edited normally in Trypanosoma equiperdum (ATCC 30019) which has kDNA sequence deletion and duplication.

H H Shu1, K Stuart.   

Abstract

Analyses of the Trypanosoma equiperdum (ATCC 30019) maxicircle reveals deletions, duplications and rearrangement compared to T. brucei. The genes for 9S rRNA and 12 proteins are absent. The 12S rRNA and cytochrome oxidase subunit I (COI) genes lack their 3' ends and are adjacent indicating deletion of intervening genes. The remaining two NADH dehydrogenase subunit genes (ND4 and ND5), the ribosomal protein RPS12 gene and the CR5 gene are duplicated and rearranged. ND4, RPS12 and the CR4 transcripts are abundant in steady state RNA while 12S rRNA and COI transcripts are not detected. Full length ND5 transcripts are rare, if present, but chimeric ND5/ND4 transcripts are abundant. The CR4 and RPS12 transcripts are the size of unedited RNAs suggesting that they are processed. However, they are not edited normally, presumably due to the absence of minicircle gRNA genes.

Entities:  

Mesh:

Substances:

Year:  1994        PMID: 8202373      PMCID: PMC308051          DOI: 10.1093/nar/22.9.1696

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN: 0305-1048            Impact factor:   16.971


  25 in total

1.  The nucleotide sequence of the variable region in Trypanosoma brucei completes the sequence analysis of the maxicircle component of mitochondrial kinetoplast DNA.

Authors:  P Sloof; A de Haan; W Eier; M van Iersel; E Boel; H van Steeg; R Benne
Journal:  Mol Biochem Parasitol       Date:  1992-12       Impact factor: 1.759

2.  Kinetoplast DNA OF Trypanosoma brucei: physical map of the maxicircle.

Authors:  K Stuart
Journal:  Plasmid       Date:  1979-10       Impact factor: 3.466

3.  Mapping and 5' end determination of kinetoplast maxicircle gene transcripts from Leishmania tarentolae.

Authors:  A M Simpson; N Neckelmann; V F de la Cruz; M L Muhich; L Simpson
Journal:  Nucleic Acids Res       Date:  1985-08-26       Impact factor: 16.971

Review 4.  Kinetoplast DNA.

Authors:  P Borst; J H Hoeijmakers
Journal:  Plasmid       Date:  1979-01       Impact factor: 3.466

5.  Structural organization of the maxicircle variable region of Trypanosoma brucei: identification of potential replication origins and topoisomerase II binding sites.

Authors:  P J Myler; D Glick; J E Feagin; T H Morales; K D Stuart
Journal:  Nucleic Acids Res       Date:  1993-02-11       Impact factor: 16.971

6.  Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.

Authors:  R Brun
Journal:  Acta Trop       Date:  1979-09       Impact factor: 3.112

7.  Restriction cleavage map of kinetoplast DNA minicircles from Trypanosoma equiperdum.

Authors:  G Riou; M Barrois
Journal:  Biochem Biophys Res Commun       Date:  1979-09-27       Impact factor: 3.575

8.  The kinetoplast DNA of Trypanosoma equiperdum.

Authors:  A C Frasch; S L Hajduk; J H Hoeijmakers; P Borst; E Brunel; J Davison
Journal:  Biochim Biophys Acta       Date:  1980-05-30

9.  Complete nucleotide sequence of minicircle kinetoplast DNA from Trypanosoma equiperdum.

Authors:  M Barrois; G Riou; F Galibert
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

10.  Characterization of the molecular components in kinetoplast-mitochondrial DNA of Trypanosoma equiperdum. Comparative study of the dyskinetoplastic and wild strains.

Authors:  G F Riou; J M Saucier
Journal:  J Cell Biol       Date:  1979-07       Impact factor: 10.539

View more
  5 in total

Review 1.  RNA editing in kinetoplastid protozoa.

Authors:  K Stuart; T E Allen; S Heidmann; S D Seiwert
Journal:  Microbiol Mol Biol Rev       Date:  1997-03       Impact factor: 11.056

Review 2.  Evolution of RNA editing in trypanosome mitochondria.

Authors:  L Simpson; O H Thiemann; N J Savill; J D Alfonzo; D A Maslov
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

3.  Molecular profiles of Trypanosoma brucei, T. evansi and T. equiperdum stocks revealed by the random amplified polymorphic DNA method.

Authors:  Zhao-Rong Lun; An-Xing Li; Xiao-Guang Chen; Li-Xin Lu; Xing-Quan Zhu
Journal:  Parasitol Res       Date:  2004-01-16       Impact factor: 2.289

4.  Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei.

Authors:  De-Hua Lai; Hassan Hashimi; Zhao-Rong Lun; Francisco J Ayala; Julius Lukes
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-01       Impact factor: 11.205

5.  The compositional landscape of minicircle sequences isolated from active lesions and scars of American cutaneous leishmaniasis.

Authors:  Eduardo Henrique Gomes Rodrigues; Fábia Carla da Silva Soares; Roberto Pereira Werkhäuser; Maria Edileuza F de Brito; Octavio Fernandes; Frederico G Coutinho Abath; Adeilton Brandão
Journal:  Parasit Vectors       Date:  2013-08-07       Impact factor: 3.876

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.