Biochemical and functional approaches to study of fatty acid requirements for very premature infants.

Plasma and RBC omega-6 and omega-3 fatty acids reflect the composition of these fatty acids in the diet, and their analyses seem unlikely to add little more to studies on infant fatty acid requirements than evidence that the milk or formula diet was adhered to. Tests of visual function, cognitive, and motor skill development, however, are sufficiently sensitive to demonstrate significant differences between groups of infants fed diets that differ only in fatty acid composition. These functional tests offer the potential for future research with modified formulas or expressed milk to determine not only fatty acid requirements but also to further fundamental understanding of the role of specific omega-6 and omega-3 fatty acids in CNS development and function.