Literature DB >> 8199342

Sparing of NADPH-diaphorase striatal neurons in Parkinson's and Alzheimer's diseases.

E J Mufson1, M M Brandabur.   

Abstract

The free radical neuromodulator, nitric oxide (NO) has been implicated as a neurotoxin. Neurons containing NO synthase (NOS) also contain NADPH-diaphorase (NADPH-d) and are resistant to NO toxicity. We report that NADPH-d-containing neurons within the striatum are spared in patients with Parkinson's (PD) and Alzheimer's disease (AD). However, a number of these neurons in both diseases appeared shrunken or bulbous with foreshortened dendritic processes. Quantitative analysis of cell areas revealed a significant difference only in the size of putamenal AD neurons which were decreased compared to normal controls. The possible involvement of NO in the neuropathogenesis of striatal derangement is discussed.

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Year:  1994        PMID： 8199342     DOI： 10.1097/00001756-199402000-00011

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

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9.  Topographical distribution and morphology of NADPH-diaphorase-stained neurons in the human claustrum.

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Journal:  Front Syst Neurosci       Date:  2014-05-27

Review 10.  A Neurotoxic Ménage-à-trois: Glutamate, Calcium, and Zinc in the Excitotoxic Cascade.

Authors:  Alberto Granzotto; Lorella M T Canzoniero; Stefano L Sensi
Journal:  Front Mol Neurosci       Date:  2020-11-26       Impact factor: 5.639
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