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Literature DB >> 7675011

Alcohol and the brain: what's NO got to do with it?

Abstract

A potential role for nitric oxide in alcohol-induced changes in brain function is discussed. Chronic alcohol exposure may lead to excitotoxicity partially due to increased levels of nitric oxide (NO). Excessive NO has been linked to cytotoxicity in neurons, glia and myelin. Cytokines produced in response to cell injury may trigger increased production of NO. These events may be involved in alcohol-induced brain damage. Formation of NO has recently been linked to increased preference for and tolerance to alcohol. A hypothesis for prevention and treatment of alcohol-induced brain damage, and craving and alcohol intake by alcoholics is proposed.

Entities: Chemical Disease

Mesh：

Substances：
Nitric Oxide
Ethanol

Year: 1995 PMID： 7675011 DOI： 10.1007/bf01991860

Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584

49 in total

Review 1. Nitric oxide, a novel neuronal messenger.

Authors: D S Bredt; S H Snyder
Journal: Neuron Date: 1992-01 Impact factor: 17.173

2. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria.

Authors: I A Clark; K A Rockett; W B Cowden
Journal: Lancet Date: 1992-10-10 Impact factor: 79.321

3. NO news is good news.

Authors: A Grossman
Journal: Endocrinology Date: 1994-03 Impact factor: 4.736

4. Localization of nitric oxide synthase indicating a neural role for nitric oxide.

Authors: D S Bredt; P M Hwang; S H Snyder
Journal: Nature Date: 1990-10-25 Impact factor: 49.962

5. Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications.

Authors: T Horn; P M Smith; B E McLaughlin; L Bauce; G S Marks; Q J Pittman; A V Ferguson
Journal: Am J Physiol Date: 1994-01

6. Suppression by ethanol of pressor response caused by the inhibition of nitric oxide synthesis.

Authors: Y X Wang; C C Pang
Journal: Eur J Pharmacol Date: 1993-03-23 Impact factor: 4.432

7. Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.

Authors: S Z Wang; S Z Zhu; E E el-Fakahany
Journal: J Pharmacol Exp Ther Date: 1994-02 Impact factor: 4.030

Review 8. Tetrahydrobiopterin and cytokines.

Authors: E R Werner; G Werner-Felmayer; H Wachter
Journal: Proc Soc Exp Biol Med Date: 1993-05

9. Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide.

Authors: M A Muñoz-Fernández; E Cano; C A O'Donnell; J Doyle; F Y Liew; M Fresno
Journal: J Neurochem Date: 1994-04 Impact factor: 5.372

Alcohol and the brain: what's NO got to do with it?

Review 1. Nitric oxide, a novel neuronal messenger.

2. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria.

3. NO news is good news.

4. Localization of nitric oxide synthase indicating a neural role for nitric oxide.

5. Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications.

6. Suppression by ethanol of pressor response caused by the inhibition of nitric oxide synthesis.

7. Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.

Review 8. Tetrahydrobiopterin and cytokines.

9. Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide.

10. Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP.

1. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates.

2. Potential effects of L-NAME on alcohol-induced oxidative stress.

3. Ethanol transiently suppresses choline-acetyltransferase in basal nucleus of Meynert slices.

4. Safety and tolerability of sauna detoxification for the protracted withdrawal symptoms of substance abuse.