Literature DB >> 8198967

Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.

M Ohnishi1, S Kimura, M Yamazaki, H Oshima, D I Mizuno, S Abe, H Yamaguchi.   

Abstract

A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As part of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.

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Year:  1994        PMID： 8198967      PMCID： PMC1969440          DOI： 10.1038/bjc.1994.204

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

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Authors:  J A Rudbach; J L Cantrell; J T Ulrich; M S Mitchell
Journal:  Adv Exp Med Biol       Date:  1990       Impact factor: 2.622

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Authors:  C Galanos; O Lüderitz; E T Rietschel; O Westphal; H Brade; L Brade; M Freudenberg; U Schade; M Imoto; H Yoshimura
Journal:  Eur J Biochem       Date:  1985-04-01

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Authors:  J Gmeiner; O Lüderitz; O Westphal
Journal:  Eur J Biochem       Date:  1969-01

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Authors:  D Mizuno; O Yoshioka; M Akamatu; T Kataoka
Journal:  Cancer Res       Date:  1968-08       Impact factor: 12.701

5.  Different structural requirements of endotoxic glycolipid for tumor regression and endotoxic activity.

Authors:  K Amano; E Ribi; J L Cantrell
Journal:  Biochem Biophys Res Commun       Date:  1982-06-15       Impact factor: 3.575

6.  Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant.

Authors:  S Kotani; H Takada; M Tsujimoto; T Ogawa; I Takahashi; T Ikeda; K Otsuka; H Shimauchi; N Kasai; J Mashimo
Journal:  Infect Immun       Date:  1985-07       Impact factor: 3.441

7.  Combination antitumor therapy with lentinan and bacterial lipopolysaccharide against murine tumors.

Authors:  S Abe; O Yoshioka; Y Masuko; J Tsubouchi; M Kohno; H Nakajima; M Yamazaki; D Mizono
Journal:  Gan       Date:  1982-02

8.  Intratumoral induction of tumour necrosis factor by systemic administration of Bordetella pertussis vaccine.

Authors:  H Minagawa; H Kobayashi; H Yoshida; M Teranishi; A Morikawa; S Abe; H Oshima; D I Mizuno
Journal:  Br J Cancer       Date:  1990-09       Impact factor: 7.640

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Authors:  M J Berendt; R J North; D P Kirstein
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307

10.  Endogenous tumor necrosis factor induction with Bordetella pertussis vaccine as a triggering agent and its therapeutic effect on MM46 carcinoma-bearing mice.

Authors:  H Minagawa; Y Kakamu; H Yoshida; F Tomita; H Oshima; D Mizuno
Journal:  Jpn J Cancer Res       Date:  1988-03
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  1 in total

1.  Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ.

Authors:  Hiromi Okuyama; Akira Tominaga; Satoshi Fukuoka; Takahiro Taguchi; Yutaka Kusumoto; Shiro Ono
Journal:  Oncol Rep       Date:  2017-01-02       Impact factor: 3.906
  1 in total

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