Literature DB >> 2579812

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities.

C Galanos, O Lüderitz, E T Rietschel, O Westphal, H Brade, L Brade, M Freudenberg, U Schade, M Imoto, H Yoshimura.   

Abstract

The recently chemically synthesized Escherichia coli lipid A and the natural free lipid A of E. coli were compared with respect to their endotoxic activities in the following test systems: lethal toxicity, pyrogenicity, local Shwartzman reactivity, Limulus amoebocyte lysate gelation capacity, tumour necrotizing activity, B cell mitogenicity, induction of prostaglandin synthesis in macrophages, and antigenic specificity. It was found that synthetic and natural free lipid A exhibit identical activities and are indistinguishable in all tests.

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Year:  1985        PMID： 2579812     DOI： 10.1111/j.1432-1033.1985.tb08798.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  125 in total

1.  E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide.

Authors:  T Kawata; J R Bristol; D P Rossignol; J R Rose; S Kobayashi; H Yokohama; A Ishibashi; W J Christ; K Katayama; I Yamatsu; Y Kishi
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

2.  The internalization time course of a given lipopolysaccharide chemotype does not correspond to its activation kinetics in monocytes.

Authors:  A Lentschat; V T El-Samalouti; J Schletter; S Kusumoto; L Brade; E T Rietschel; J Gerdes; M Ernst; H Flad; A J Ulmer
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

Review 3.  Bloodstream infections: epidemiology, pathophysiology and therapeutic perspectives.

Authors:  R Salomão; O Rigato; A C Pignatari; M A Freudenberg; C Galanos
Journal:  Infection       Date:  1999 Jan-Feb       Impact factor: 3.553

Review 4.  The biology of endotoxin.

Authors:  H Heine; E T Rietschel; A J Ulmer
Journal:  Mol Biotechnol       Date:  2001-11       Impact factor: 2.695

Review 5.  Lipopolysaccharide endotoxins.

Authors:  Christian R H Raetz; Chris Whitfield
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

6.  Characterization of the epitope specificity of murine monoclonal antibodies directed against lipid A.

Authors:  H M Kuhn; L Brade; B J Appelmelk; S Kusumoto; E T Rietschel; H Brade
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

7.  Biological activity of bacterial surface components: bacterial extracts and defined bacterial cell wall components as immunomodulators.

Authors:  W G Bessler; B Kleine; C Martinez Alonso; L Biesert; M Strecker; K H Wiesmüller; J Metzger; G Jung
Journal:  Lung       Date:  1990       Impact factor: 2.584

8.  Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway.

Authors:  Susu M Zughaier; Yih-Ling Tzeng; Shanta M Zimmer; Anup Datta; Russell W Carlson; David S Stephens
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

9.  Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice.

Authors:  Marco A Campos; Gracia M S Rosinha; Igor C Almeida; Xirlene S Salgueiro; Bruce W Jarvis; Gary A Splitter; Nilofer Qureshi; Oscar Bruna-Romero; Ricardo T Gazzinelli; Sergio C Oliveira
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

10.  Anti-endotoxin agents. 2. Pilot high-throughput screening for novel lipopolysaccharide-recognizing motifs in small molecules.

Authors:  Stewart J Wood; Kelly A Miller; Sunil A David
Journal:  Comb Chem High Throughput Screen       Date:  2004-12       Impact factor: 1.339
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