PURPOSE: To determine the dose of contrast medium and the imaging strategy sufficient to detect diffusion of low-molecular-weight gadolinium-containing contrast media into normal intervertebral disks. METHODS: In 11 rabbits, sequential MR images were obtained of the spine for 120 minutes after intravenous injection of gadopentetate dimeglumine in doses of 0.1 to 2.8 mmol/kg. Images were inspected for evidence of contrast enhancement. Signal intensity was measured and plotted as a function of time and dose. RESULTS: Contrast enhancement was detected by inspection of images and by measurement in animals receiving doses of 0.3 mmol/kg and larger. CONCLUSIONS: Diffusion of gadolinium-containing chelates into the intervertebral disk can be detected with clinically used doses of commercially available contrast medium. Therefore, with MR and a gadolinium-containing contrast medium, diffusion into intervertebral disks can be studied.
PURPOSE: To determine the dose of contrast medium and the imaging strategy sufficient to detect diffusion of low-molecular-weight gadolinium-containing contrast media into normal intervertebral disks. METHODS: In 11 rabbits, sequential MR images were obtained of the spine for 120 minutes after intravenous injection of gadopentetate dimeglumine in doses of 0.1 to 2.8 mmol/kg. Images were inspected for evidence of contrast enhancement. Signal intensity was measured and plotted as a function of time and dose. RESULTS: Contrast enhancement was detected by inspection of images and by measurement in animals receiving doses of 0.3 mmol/kg and larger. CONCLUSIONS: Diffusion of gadolinium-containing chelates into the intervertebral disk can be detected with clinically used doses of commercially available contrast medium. Therefore, with MR and a gadolinium-containing contrast medium, diffusion into intervertebral disks can be studied.
Authors: Arijitt Borthakur; Philip M Maurer; Matthew Fenty; Chenyang Wang; Rachelle Berger; Jonathon Yoder; Richard A Balderston; Dawn M Elliott Journal: Spine (Phila Pa 1976) Date: 2011-12-01 Impact factor: 3.468
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Authors: An M Nguyen; Wade Johannessen; Jonathon H Yoder; Andrew J Wheaton; Edward J Vresilovic; Arijitt Borthakur; Dawn M Elliott Journal: J Bone Joint Surg Am Date: 2008-04 Impact factor: 5.284