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Literature DB >> 8194529

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair.

S Humbert¹, H van Vuuren, Y Lutz, J H Hoeijmakers, J M Egly, V Moncollin.

Abstract

The human BTF2 (TFIIH) transcription factor is a multisubunit protein involved in transcription initiation by RNA polymerase II (B) as well as in DNA repair. In addition to the previously characterized p62 and p89/ERCC3 subunits, we have cloned two other subunits of BTF2, p44 and p34. The gene encoding p44 appeared to be the human counterpart of SSL1, a gene involved in translation and UV resistance in yeast. Interestingly, the p34 subunit also has homology with a domain of SSL1, suggesting that it corresponds to an as yet unidentified protein involved in DNA repair. Both p44 and p34 possess zinc finger domains that may mediate BTF2 binding to nucleic acids.

Entities: Chemical

Mesh：

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Year: 1994 PMID： 8194529 PMCID： PMC395104 DOI： 10.1002/j.1460-2075.1994.tb06523.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

23 in total

1. A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

Authors: H Serizawa; R C Conaway; J W Conaway
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

2. Transcription-coupled DNA repair.

Authors: K S Sweder; P C Hanawalt
Journal: Science Date: 1993-10-15 Impact factor: 47.728

3. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes.

Authors: D A Hager; R R Burgess
Journal: Anal Biochem Date: 1980-11-15 Impact factor: 3.365

4. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.

Authors: L Schaeffer; R Roy; S Humbert; V Moncollin; W Vermeulen; J H Hoeijmakers; P Chambon; J M Egly
Journal: Science Date: 1993-04-02 Impact factor: 47.728

5. SSL1, a suppressor of a HIS4 5'-UTR stem-loop mutation, is essential for translation initiation and affects UV resistance in yeast.

Authors: H Yoon; S P Miller; E K Pabich; T F Donahue
Journal: Genes Dev Date: 1992-12 Impact factor: 11.361

6. Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase.

Authors: O Gileadi; W J Feaver; R D Kornberg
Journal: Science Date: 1992-09-04 Impact factor: 47.728

7. Determination of the base recognition positions of zinc fingers from sequence analysis.

Authors: G H Jacobs
Journal: EMBO J Date: 1992-12 Impact factor: 11.598

8. Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.

Authors: A J van Vuuren; E Appeldoorn; H Odijk; A Yasui; N G Jaspers; D Bootsma; J H Hoeijmakers
Journal: EMBO J Date: 1993-09 Impact factor: 11.598

9. The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.

Authors: L Schaeffer; V Moncollin; R Roy; A Staub; M Mezzina; A Sarasin; G Weeda; J H Hoeijmakers; J M Egly
Journal: EMBO J Date: 1994-05-15 Impact factor: 11.598

10. Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).

Authors: A J van Vuuren; W Vermeulen; L Ma; G Weeda; E Appeldoorn; N G Jaspers; A J van der Eb; D Bootsma; J H Hoeijmakers; S Humbert
Journal: EMBO J Date: 1994-04-01 Impact factor: 11.598

30 in total

Review 1. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.

Authors: Charles A Whittaker; Richard O Hynes
Journal: Mol Biol Cell Date: 2002-10 Impact factor: 4.138

2. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

Authors: J T Reardon; H Ge; E Gibbs; A Sancar; J Hurwitz; Z Q Pan
Journal: Proc Natl Acad Sci U S A Date: 1996-06-25 Impact factor: 11.205

3. Novel mutations in the RAD3 and SSL1 genes perturb genome stability by stimulating recombination between short repeats in Saccharomyces cerevisiae.

Authors: S Maines; M C Negritto; X Wu; G M Manthey; A M Bailis
Journal: Genetics Date: 1998-11 Impact factor: 4.562

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair.

1. A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

2. Transcription-coupled DNA repair.

3. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes.

4. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.

5. SSL1, a suppressor of a HIS4 5'-UTR stem-loop mutation, is essential for translation initiation and affects UV resistance in yeast.

6. Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase.

7. Determination of the base recognition positions of zinc fingers from sequence analysis.

8. Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.

9. The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.

10. Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).

Review 1. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.

2. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

3. Novel mutations in the RAD3 and SSL1 genes perturb genome stability by stimulating recombination between short repeats in Saccharomyces cerevisiae.

4. Maternal mosaicism for a second mutational event in a type I spinal muscular atrophy family.

Review 5. Molecular genetics of the RNA polymerase II general transcriptional machinery.

6. Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins.

7. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.

8. Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.

9. Functional interchangeability of TFIIIB components from yeast and human cells in vitro.

10. An interaction between the Tfb1 and Ssl1 subunits of yeast TFIIH correlates with DNA repair activity.