Literature DB >> 9799251

Novel mutations in the RAD3 and SSL1 genes perturb genome stability by stimulating recombination between short repeats in Saccharomyces cerevisiae.

S Maines1, M C Negritto, X Wu, G M Manthey, A M Bailis.   

Abstract

Maintaining genome stability requires that recombination between repetitive sequences be avoided. Because short, repetitive sequences are the most abundant, recombination between sequences that are below a certain length are selectively restricted. Novel alleles of the RAD3 and SSL1 genes, which code for components of a basal transcription and UV-damage-repair complex in Saccharomyces cerevisiae, have been found to stimulate recombination between short, repeated sequences. In double mutants, these effects are suppressed, indicating that the RAD3 and SSL1 gene products work together in influencing genome stability. Genetic analysis indicates that this function is independent of UV-damage repair and mutation avoidance, supporting the notion that RAD3 and SSL1 together play a novel role in the maintenance of genome integrity.

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Year:  1998        PMID： 9799251      PMCID： PMC1460400     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  48 in total

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Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

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Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

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Authors:  C Rayssiguier; D S Thaler; M Radman
Journal:  Nature       Date:  1989-11-23       Impact factor: 49.962

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Journal:  Annu Rev Genet       Date:  1988       Impact factor: 16.830

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Authors:  A S Waldman; R M Liskay
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

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Authors:  D R Wilcox; L Prakash
Journal:  J Bacteriol       Date:  1981-11       Impact factor: 3.490

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Authors:  J W Wallis; G Chrebet; G Brodsky; M Rolfe; R Rothstein
Journal:  Cell       Date:  1989-07-28       Impact factor: 41.582

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Authors:  A Hinnen; J B Hicks; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

9.  The genetic control of direct-repeat recombination in Saccharomyces: the effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene.

Authors:  B J Thomas; R Rothstein
Journal:  Genetics       Date:  1989-12       Impact factor: 4.562

10.  Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.

Authors:  A E Gorbalenya; E V Koonin; A P Donchenko; V M Blinov
Journal:  Nucleic Acids Res       Date:  1989-06-26       Impact factor: 16.971
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  15 in total

1.  Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44.

Authors:  Jin Seok Kim; Charlotte Saint-André; Hye Seong Lim; Cheol-Sang Hwang; Jean Marc Egly; Yunje Cho
Journal:  J Biol Chem       Date:  2015-02-13       Impact factor: 5.157

2.  Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.

Authors:  M C Negritto; J Qiu; D O Ratay; B Shen; A M Bailis
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

3.  Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.

Authors:  B S Lee; L Bi; D J Garfinkel; A M Bailis
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

4.  Constitutively active Artemis nuclease recognizes structures containing single-stranded DNA configurations.

Authors:  Nicholas R Pannunzio; Michael R Lieber
Journal:  DNA Repair (Amst)       Date:  2019-07-26

5.  The DNA repair genes XPB and XPD defend cells from retroviral infection.

Authors:  Kristine Yoder; Alain Sarasin; Kenneth Kraemer; Michael McIlhatton; Frederic Bushman; Richard Fishel
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-13       Impact factor: 11.205

6.  Multiple pathways promote short-sequence recombination in Saccharomyces cerevisiae.

Authors:  Glenn M Manthey; Adam M Bailis
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

7.  A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.

Authors:  Michelle S Navarro; Liu Bi; Adam M Bailis
Journal:  Genetics       Date:  2007-05-04       Impact factor: 4.562

8.  Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.

Authors:  Erica Mito; Janet V Mokhnatkin; Molly C Steele; Victoria L Buettner; Steve S Sommer; Glenn M Manthey; Adam M Bailis
Journal:  Genetics       Date:  2008-08       Impact factor: 4.562

9.  Msh2 blocks an alternative mechanism for non-homologous tail removal during single-strand annealing in Saccharomyces cerevisiae.

Authors:  Glenn M Manthey; Nilan Naik; Adam M Bailis
Journal:  PLoS One       Date:  2009-10-16       Impact factor: 3.240

10.  RAD59 and RAD1 cooperate in translocation formation by single-strand annealing in Saccharomyces cerevisiae.

Authors:  Nicholas R Pannunzio; Glenn M Manthey; Adam M Bailis
Journal:  Curr Genet       Date:  2009-12-11       Impact factor: 3.886
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