Literature DB >> 819289

Synthesis and in vitro cytotoxic activity of new n-diazoacetylglycine derivatives.

R D Loggia, A Furlani, F Savastano, V Scarcia.   

Abstract

The syntheses of various N-diazoacetylglycine derivatives are described. The results of an in vitro screening carried out on KB cells for cytotoxic activity are reported. The most active compounds are DGE, DGiBA and DGHA. A possible relationship between the activity and the liposolubility of these compounds is discussed.

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Year:  1976        PMID： 819289     DOI： 10.1007/BF01990207

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Nutrition needs of mammalian cells in tissue culture.

Authors:  H EAGLE
Journal:  Science       Date:  1955-09-16       Impact factor: 47.728

2.  Propagation in a fluid medium of a human epidermoid carcinoma, strain KB.

Authors:  H EAGLE
Journal:  Proc Soc Exp Biol Med       Date:  1955-07

3.  Effects of some N-diazoacetyl-glycine derivatives on the growth of E. coli.

Authors:  T Giraldi; C M Bragadin; R Della Loggia
Journal:  Experientia       Date:  1974-05-15

4.  The immunodepressive activity of N-diazoacetylglycine amide in some transplantation systems.

Authors:  G Brambilla; S Parodi; M Cavanna; L Baldini
Journal:  Transplantation       Date:  1970-07       Impact factor: 4.939

5.  Effects of diazoacetyl-glycine amide on purine nucleotide and deoxyribonucleic acid synthesis in Ehrlich ascites tumor cells.

Authors:  T Giraldi; G Steppani; L Baldini
Journal:  Biochem Pharmacol       Date:  1972-11-15       Impact factor: 5.858

6.  Mechanism of the mutagenic activity of diazoacetylglycine derivatives.

Authors:  E Banfi; M Tamaro; B Pani; C Monti-Bragadin
Journal:  Boll Ist Sieroter Milan       Date:  1974

7.  The immunodepressive activity of N-diazoacetylglycine derivatives in mice.

Authors:  G Brambilla; M Cavanna; A Maura; S Parodi; A Furlani; V Scarcia; R Della Loggia
Journal:  Arzneimittelforschung       Date:  1973-05

8.  Sequence peptide polymers. I. Polymers based on aspartic acid and glycine.

Authors:  D F DeTar; M Gouge; W Honsberg; U Honsberg
Journal:  J Am Chem Soc       Date:  1967-02-15       Impact factor: 15.419

9.  Mutagenic activity of diazoacetylglycine derivatives.

Authors:  C Monti-Bragadin; M Tamaro; E Banfi
Journal:  Antimicrob Agents Chemother       Date:  1974-11       Impact factor: 5.191

10.  [An effective immunodepressive treatment for demonstrating in allogeneic mice the tumorigenic properties of cells grown in vitro (author's transl)].

Authors:  S Parodi; M Cavanna; R Finollo; G Brambilla; A Furlani; V Scarcia
Journal:  Tumori       Date:  1975 May-Jun
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  1 in total

1.  DNA damage and repair induced by diazoacetyl derivatives of amino acids with different mechanism of cytotoxicity. Correlations with mutagenicity and carcinogenicity.

Authors:  G Brambilla; M Cavanna; P Carlo; R Finollo; L Sciaba; S Parodi; C Bolognesi
Journal:  J Cancer Res Clin Oncol       Date:  1979-05-14       Impact factor: 4.553
  1 in total

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