Literature DB >> 8192656

Rat liver mitochondrial ADP-ribose pyrophosphatase in the matrix space with low Km for free ADP-ribose.

D Bernet1, R M Pinto, M J Costas, J Canales, J C Cameselle.   

Abstract

A study involving markers of subcellular and submitochondrial fractions, gradient centrifugation, latency measurements and extraction with digitonin, demonstrates the association of a specific ADP-ribose pyrophosphatase with rat liver mitochondria and its localization in the matrix space. The enzyme hydrolyses ADP-ribose to AMP, with a Km of 2-3 microM. The results support the occurrence of a specific turnover pathway for free ADP-ribose and its relevance in mitochondria.

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Year:  1994        PMID： 8192656      PMCID： PMC1138074          DOI： 10.1042/bj2990679

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

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Authors:  M A Matlib; P J O'Brien
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Authors:  S Tanuma; H Endo
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Authors:  A Miró; M J Costas; M García-Díaz; M T Hernández; J C Cameselle
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Journal:  Biochemistry       Date:  1987-04-07       Impact factor: 3.162

5.  Subcellular fractionation of rat liver.

Authors:  S Fleischer; M Kervina
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

6.  Mono(ADP-ribosylation) in rat liver mitochondria.

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Authors:  M J Costas; J C Cameselle; A Sillero
Journal:  J Biol Chem       Date:  1986-02-15       Impact factor: 5.157

8.  Two low Km hydrolytic activities on dinucleoside 5',5"'-P1,P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase I-like enzyme.

Authors:  J C Cameselle; M J Costas; M A Günther Sillero; A Sillero
Journal:  J Biol Chem       Date:  1984-03-10       Impact factor: 5.157

9.  Nonenzymic ADP-ribosylation of specific mitochondrial polypeptides.

Authors:  H Hilz; R Koch; W Fanick; K Klapproth; P Adamietz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

10.  Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.

Authors:  D M Parry; P L Pedersen
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157
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  2 in total

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