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Literature DB >> 3036216

ADP-ribosyl transferase and NAD glycohydrolase activities in rat liver mitochondria.

Abstract

ADP-ribosyl transferase and NAD glycohydrolase activities have been estimated in mitochondria in mitoplasts as well as in other submitochondrial fractions. A high activity of these two enzymes was present in mitoplasts as compared to the outer membrane preparation or intermembrane compartment. Inhibitor studies provide strong evidence for the involvement of ADP-ribosyl transferase in the process of ADP-ribosylation of mitochondrial proteins. When NAD glycohydrolase was blocked by nicotinamide or 3-aminobenzamide, the incorporation of ADP-ribose into mitochondrial proteins still occurs. ADP-ribosyl transferase activity could also be detected when NAD glycohydrolase was separated by hydroxylapatite chromatography. The protein-linked ADP-ribose moiety appears to be an oligomer in mitochondria.

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Year: 1987 PMID： 3036216 DOI： 10.1021/bi00381a027

Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162

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Cited

13 in total

1. Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria.

Authors: A Herrero-Yraola; S M Bakhit; P Franke; C Weise; M Schweiger; D Jorcke; M Ziegler
Journal: EMBO J Date: 2001-05-15 Impact factor: 11.598

2. Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase.

Authors: M Ziegler; D Jorcke; M Schweiger
Journal: Biochem J Date: 1997-09-01 Impact factor: 3.857

3. 3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism.

Authors: Joram Wardi; Orna Ernst; Anna Lilja; Hussein Aeed; Sebastián Katz; Idan Ben-Nachum; Iris Ben-Dror; Dolev Katz; Olga Bernadsky; Rajendar Kandhikonda; Yona Avni; Iain D C Fraser; Roy Weinstain; Alexander Biro; Tsaffrir Zor
Journal: Dig Dis Sci Date: 2018-09-08 Impact factor: 3.199

9. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.

Authors: Marianna N Rossi; Mariarosaria Carbone; Cassandra Mostocotto; Carmine Mancone; Marco Tripodi; Rossella Maione; Paolo Amati
Journal: J Biol Chem Date: 2009-09-17 Impact factor: 5.157

10. The rapid response of isolated mitochondrial particles to 0.1 nM-tri-iodothyronine correlates with the ADP-ribosylation of a single inner-membrane protein.

Authors: D L Hardy; J Mowbray
Journal: Biochem J Date: 1992-05-01 Impact factor: 3.857

ADP-ribosyl transferase and NAD glycohydrolase activities in rat liver mitochondria.

1. Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria.

2. Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase.

3. 3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism.

4. Enzymic, cysteine-specific ADP-ribosylation in bovine liver mitochondria.

5. Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells.

Review 6. Sex differences in mitochondrial (dys)function: Implications for neuroprotection.

Review 7. Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work.

8. Rat liver mitochondrial ADP-ribose pyrophosphatase in the matrix space with low Km for free ADP-ribose.

9. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.

10. The rapid response of isolated mitochondrial particles to 0.1 nM-tri-iodothyronine correlates with the ADP-ribosylation of a single inner-membrane protein.