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Literature DB >> 8192466

Physicochemical cell damage in relation to lethal amphotericin B action.

Abstract

A direct relationship between the concentration-dependent rate of amphotericin B-induced K+ release from Candida albicans and the concentration-dependent rate of killing by the drug was established. This relationship together with the observed rapidity of both release and killing action supports the conclusion that the lethal action of amphotericin B is primarily physicochemical in nature.

Entities: Chemical Species

Mesh：

Substances：

Year: 1994 PMID： 8192466 PMCID： PMC284457 DOI： 10.1128/AAC.38.2.363

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1. Direct membrane damage and miconazole lethality.

Authors: W H Beggs
Journal: Res Commun Chem Pathol Pharmacol Date: 1992-08

Review 2. Amphotericin B: current understanding of mechanisms of action.

Authors: J Brajtburg; W G Powderly; G S Kobayashi; G Medoff
Journal: Antimicrob Agents Chemother Date: 1990-02 Impact factor: 5.191

3. The release of potassium ions from Candida albicans in the presence of polyene antibiotics.

Authors: E F Gale
Journal: J Gen Microbiol Date: 1974-02

Review 4. Nature and development of phenotypic resistance to amphotericin B in Candida albicans.

Authors: E F Gale
Journal: Adv Microb Physiol Date: 1986 Impact factor: 3.517

Review 5. Mode of action of clinically important antifungal drugs.

Authors: D Kerridge
Journal: Adv Microb Physiol Date: 1986 Impact factor: 3.517

Review 6. Amphotericin B: 30 years of clinical experience.

Authors: H A Gallis; R H Drew; W W Pickard
Journal: Rev Infect Dis Date: 1990 Mar-Apr

7. Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans.

Authors: W C Chen; D L Chou; D S Feingold
Journal: Antimicrob Agents Chemother Date: 1978-06 Impact factor: 5.191

Review 8. Systemically administered antifungal agents. A review of their clinical pharmacology and therapeutic applications.

Authors: C A Lyman; T J Walsh
Journal: Drugs Date: 1992-07 Impact factor: 9.546

9. Mechanism of inactivation of the polyene antibiotic amphotericin B. Evidence for radical formation in the process of autooxidation.

Authors: M T Lamy-Freund; V F Ferreira; S Schreier
Journal: J Antibiot (Tokyo) Date: 1985-06 Impact factor: 2.649

9 in total

8 in total

1. Assessment of the effect of amphotericin B on the vitality of Candida albicans.

Authors: R S Liao; R P Rennie; J A Talbot
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

2. A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity.

Authors: Daniel S Palacios; Thomas M Anderson; Martin D Burke
Journal: J Am Chem Soc Date: 2007-10-23 Impact factor: 15.419

3. A new look at the antibiotic amphotericin B effect on Candida albicans plasma membrane permeability and cell viability functions.

Authors: Barbara Chudzik; Mateusz Koselski; Aleksandra Czuryło; Kazimierz Trębacz; Mariusz Gagoś
Journal: Eur Biophys J Date: 2015-01-04 Impact factor: 1.733

8. The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner.

Authors: Rasmus Bojsen; Rasmus Torbensen; Camilla Eggert Larsen; Anders Folkesson; Birgitte Regenberg
Journal: PLoS One Date: 2013-07-12 Impact factor: 3.240