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Literature DB >> 819192

Intestinal anaphylaxis in the rat as a model of food allergy.

Abstract

An animal model of food allergy has been developed in which some aspects of the allergic response could be quantified and the effects of various drugs evaluated. The change in permeability of the intestinal tract of actively sensitized rats, after oral challenge with the sensitizing antigen, was the parameter measured. Rats were sensitized by injection of egg albumin and B. pertussis vaccine to induce reaginic antibody to egg albumin. Two weeks after sensitization, 125I-labelled bovine serum albumin (125I-labelled BSA) was injected intravenously, followed by oral challenge with egg albumin. Pieces of intestinal tissue were obtained and the amount of 125I-labelled BSA determined in a gamma counter. The amount of 125I-labelled BSA in the intestinal tissue of sensitized and challenged rats regularly showed an increase of greater than 100% above values for control rats.

Entities: Chemical Disease Species

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Year: 1976 PMID： 819192 PMCID： PMC1538410

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

9 in total

1. MICROMETHODS FOR THE STUDY OF PROTEINS AND ANTIBODIES. IV. FACTORS INVOLVED IN THE PREPARATION AND USE OF A STABLE PREPARATION OF FORMALINIZED, TANNIC ACID-TREATED, PROTEIN-SENSITIZED ERYTHROCYTES FOR DETECTION OF ANTIGEN AND ANTIBODY.

Authors: T M DANIEL; J G WEYAND; A B STAVITSKY
Journal: J Immunol Date: 1963-05 Impact factor: 5.422

2. THE MECHANISM OF ANAPHYLAXIS. I. PRODUCTION AND BIOLOGICAL PROPERTIES OF 'MAST CELL SENSITIZING' ANTIBODY.

Authors: I MOTA
Journal: Immunology Date: 1964-11 Impact factor: 7.397

3. The altered reactivity of mice after inoculation with Bordetella pertussis vaccine.

Authors: L S KIND
Journal: Bacteriol Rev Date: 1958-09

4. Letter: Oral sodium cromoglycate in gastrointestinal allergy.

Authors: P J Kingsley
Journal: Lancet Date: 1974-10-26 Impact factor: 79.321

5. Disodium cromoglycate in gastrointestinal protein intolerance.

Authors: S Freier; H Berger
Journal: Lancet Date: 1973-04-28 Impact factor: 79.321

6. Effect of disodium cromoglycate on asthmatic reactions to alcoholic beverages.

Authors: A B Breslin; D J Hendrick; J Pepys
Journal: Clin Allergy Date: 1973-03

Review 7. Clinical and immunological perspectives in food sensitivity. A review.

Authors: G B Goldstein; D C Heiner
Journal: J Allergy Date: 1970-11

Review 8. Food allergy. The chemical nature of the substances eliciting symptoms.

Authors: E Bleumink
Journal: World Rev Nutr Diet Date: 1970 Impact factor: 0.575

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Authors: J S Cox; J E Beach; A M Blair; A J Clarke; J King; T B Lee; D E Loveday; G F Moss; T S Orr; J T Ritchie; P Sheard
Journal: Adv Drug Res Date: 1970

9 in total

10 in total

1. Typical and atypical mast cells of the rat gastrointestinal system: distribution and correlation with tissue histamine.

Authors: A M Saavedra-Delgado; S Turpin; D D Metcalfe
Journal: Agents Actions Date: 1984-01

Review 2. The mucosal mast cell and its role in gastrointestinal allergic diseases.

Authors: K E Barrett; D D Metcalfe
Journal: Clin Rev Allergy Date: 1984-02

3. Divalent hapten-induced intestinal anaphylaxis in the mouse: uptake and characterization of a bystander protein.

Authors: R E Kleinman; P R Harmatz; R A Hatz; M Brown; P D Ariniello; W A Walker; K J Bloch
Journal: Immunology Date: 1989-12 Impact factor: 7.397

4. Passage of ingested protein into the blood during gastrointestinal hypersensitivity reactions: experiments in the preruminant calf.

Authors: P J Kilshaw; H Slade
Journal: Clin Exp Immunol Date: 1980-09 Impact factor: 4.330

5. Inhibition of rat intestinal anaphylaxis by various anti-inflammatory agents.

Authors: N E Byars; R W Ferraresi
Journal: Agents Actions Date: 1980-06

6. Intestinal hypersensitivity reactions in the rat. I. Uptake of intact protein, permeability to sugars and their correlation with mucosal mast-cell activation.

Authors: M W Turner; P Boulton; J G Shields; S Strobel; S Gibson; H R Miller; R J Levinsky
Journal: Immunology Date: 1988-01 Impact factor: 7.397