Literature DB >> 8190508

[Viable meniscus transplantation].

R Verdonk1, P Van Daele, B Claus, K Vandenabeele, P Desmet, G Verbruggen, E M Veys, H Claessens.   

Abstract

The integrity of the semilunar cartilages has proved to be the best safeguard against mechanical degenerative changes. One can postulate that restoring normal congruency between the femur and tibia with intact menisci would be the ideal solution to many mechanical knee problems. Several semilunar cartilages have been transplanted with good functional results in medial and lateral compartmental meniscal disease. However, this form of chondroprotection in the load-bearing area of the femur and tibia can only be properly evaluated after 10 to 20 years of follow-up. In order to obtain functional results, meniscal allografts have to be incorporated in the knee joint by intimate meniscofemoral synovial bonding. The synovial fibroblasts must grow into the collagen meshwork of the meniscal allograft. Such ingrowth has been shown in freeze-dried and deep-frozen meniscal allografts. However, in a small number of transplants shrinking has been observed on repeat arthroscopy at 6 months. Satisfactory incorporation of meniscal allografts has been obtained with fresh allografts, but availability remains a problem when this method is used for meniscal substitution. For this reason viable meniscal allograft implantation was initiated in a series of 25 patients and the value of this method studied. The meniscal allograft can be kept in an adequate semisynthetic nutrient medium for approximately 2-3 weeks without apparent loss of viability, during which period the appropriate recipient can be selected and prepared, a thorough laboratory screening can be conducted, and the culture results and disease transmission factors can be evaluated. In this way, live transplant hazards can be avoided, resulting in a higher success rate.

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Year:  1994        PMID: 8190508

Source DB:  PubMed          Journal:  Orthopade        ISSN: 0085-4530            Impact factor:   1.087


  7 in total

Review 1.  Meniscus allograft transplantation: a current concepts review.

Authors:  James H Lubowitz; Peter C M Verdonk; John B Reid; René Verdonk
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2007-02-28       Impact factor: 4.342

2.  Defining outcome after meniscal allograft transplantation: Is buying time a valid measure of success?

Authors:  Tim Spalding; Alan Getgood
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-05       Impact factor: 4.342

3.  Arthroscopic collagen meniscus implant results at 6 to 8 years follow up.

Authors:  Stefano Zaffagnini; Giovanni Giordano; Alberto Vascellari; Danilo Bruni; Maria Pia Neri; Francesco Iacono; Elizaveta Kon; Mirco Lo Presti; Maurilio Marcacci
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2006-07-15       Impact factor: 4.342

4.  Human meniscal proteoglycan metabolism in long-term tissue culture.

Authors:  G Verbruggen; R Verdonk; E M Veys; P Van Daele; P De Smet; K Van den Abbeele; B Claus; D Baeten
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  1996       Impact factor: 4.342

5.  Normal and transplanted lateral knee menisci: evaluation of extrusion using magnetic resonance imaging and ultrasound.

Authors:  Peter Verdonk; Yves Depaepe; Stefan Desmyter; Martine De Muynck; Karl Fredrik Almqvist; Koenraad Verstraete; René Verdonk
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2004-05-14       Impact factor: 4.342

6.  Oxygen tension is a determinant of the matrix-forming phenotype of cultured human meniscal fibrochondrocytes.

Authors:  Adetola B Adesida; Aillette Mulet-Sierra; Leila Laouar; Nadr M Jomha
Journal:  PLoS One       Date:  2012-06-15       Impact factor: 3.240

7.  Establishing Clinically Significant Outcomes After Meniscal Allograft Transplantation.

Authors:  Joseph N Liu; Anirudh K Gowd; Michael L Redondo; David R Christian; Brandon C Cabarcas; Adam B Yanke; Brian J Cole
Journal:  Orthop J Sports Med       Date:  2019-01-04
  7 in total

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