Literature DB >> 819003

Dimethylnitrosamine demethylation by reconstituted liver microsomal cytochrome P-450 enzyme system.

P D Lotlikar, W J Baldy, E N Dwyer.   

Abstract

Oxidative demethylation of dimethylnitosamine was studied with both reconstituted and unresolved liver microsomal cytochrome P-450 enzyme systems from rats and hamsters. Proteinase treatment of liver microsomal preparations yielded cytochrome P-450 particulate fractions. Both cytochrome P-450 and NADPH- cytochrome c reductase fractions were required for optimum demethylation activity. Particulate cytochrome P-450 fractions were more effecient than either Triton X-100- or cholatesolubilized preparations of these particles in demethylation activity with rat and hamster liver preparations appear to be due to differences in specificity in their cytochrome P-450 fractions.

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Year:  1975        PMID： 819003      PMCID： PMC1172528          DOI： 10.1042/bj1520705

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  The determination of formaldehyde and serine in biological systems.

Authors:  W R FRISELL; C G MACKENZIE
Journal:  Methods Biochem Anal       Date:  1958

3.  Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.

Authors:  J C Kawalek; A Y Lu
Journal:  Mol Pharmacol       Date:  1975-03       Impact factor: 4.436

4.  Reconstituted hamster liver microsomal enzyme system for N-hydroxylation of the carcinogen 2-acetylaminofluorene.

Authors:  P D Lotlikar; L Luha; K Zaleski
Journal:  Biochem Biophys Res Commun       Date:  1974-08-19       Impact factor: 3.575

5.  [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors:  H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal:  Z Krebsforsch       Date:  1967

6.  Epsilon-alkyllysinase. New assay method, purification, and biological significance.

Authors:  W K Paik; S Kim
Journal:  Arch Biochem Biophys       Date:  1974-11       Impact factor: 4.013

Review 7.  Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

Authors:  J A Miller
Journal:  Cancer Res       Date:  1970-03       Impact factor: 12.701

Review 8.  Carcinogenic nitroso compounds.

Authors:  P N Magee; J M Barnes
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

9.  Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

Authors:  P Czygan; H Greim; A J Garro; F Hutterer; F Schaffner; H Popper; O Rosenthal; D Y Cooper
Journal:  Cancer Res       Date:  1973-11       Impact factor: 12.701

10.  Ring-andN-hydroxylation of 2-acetamidofluorene by rat liver reconstituted cytochrome P-450 enzyme system.

Authors:  P D Lotlikar; K Zaleski
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857
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  8 in total

1.  Biodegradation of N-nitrosodimethylamine in aqueous and soil systems.

Authors:  D L Kaplan; A M Kaplan
Journal:  Appl Environ Microbiol       Date:  1985-10       Impact factor: 4.792

2.  Effect of detergents on the N-and ring-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations.

Authors:  P D Lotlikar; E N Dwyer
Journal:  Biochem J       Date:  1976-12-15       Impact factor: 3.857

3.  Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.

Authors:  T Kawanishi; Y Ohno; A Takahashi; A Takanaka; Y Kasuya; Y Omori
Journal:  Arch Toxicol       Date:  1984-11       Impact factor: 5.153

4.  Phospholipid requirement for dimethylnitrosamine demethylation by hamster hepatic microsomal cytochrome P-450 enzyme system.

Authors:  P D Lotlikar; W J Baldy; J Nyce; E N Dwyer
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

5.  N-nitrosodialkylamine dealkylation in reconstituted systems containing cytochrome P-450 purified from phenobarbital- and beta-naphthoflavone-treated rats.

Authors:  T Kawanishi; Y Ohno; A Takanaka; S Kawano; Y Yamazoe; R Kato; Y Omori
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

6.  Metabolic activation of aromatic amines and dialkylnitrosamines.

Authors:  P D Lotlikar
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

7.  Liver injuries induced by cyclochlorotine isolated from Penicillium islandicum.

Authors:  K Terao; E Ito; T Tatsuno
Journal:  Arch Toxicol       Date:  1984-03       Impact factor: 5.153

8.  Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury.

Authors:  M I Diaz Gomez; H M Godoy; J A Castro
Journal:  Arch Toxicol       Date:  1981-06       Impact factor: 5.153
  8 in total

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