Literature DB >> 8189543

Constitutive production of alpha and beta interferons in mutant human cell lines.

R McKendry1, S Pellegrini, I M Kerr, G R Stark.   

Abstract

Alpha and beta interferons control expression of a selectable marker in the human hypoxanthine phosphoribosyltransferase-negative cell line 2fTGH, in which transcription of gpt is regulated by the upstream region of an interferon-responsive human gene. Selection of mutagenized 2fTGH cells in hypoxanthine-aminopterin-thymidine medium yielded mutants in one recessive (C1) and two dominant (C2 and C3) complementation groups. The mutants constitutively expressed low levels of beta interferon (C1), alpha interferon (C2), or both (C3).

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Year:  1994        PMID： 8189543      PMCID： PMC236917     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  54 in total

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Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

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Authors:  S Goodbourn; T Maniatis
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

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Journal:  Cold Spring Harb Symp Quant Biol       Date:  1988

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Authors:  K Zinn; T Maniatis
Journal:  Cell       Date:  1986-05-23       Impact factor: 41.582

6.  Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

Authors:  H Harada; T Fujita; M Miyamoto; Y Kimura; M Maruyama; A Furia; T Miyata; T Taniguchi
Journal:  Cell       Date:  1989-08-25       Impact factor: 41.582

7.  Involvement of a cis-element that binds an H2TF-1/NF kappa B like factor(s) in the virus-induced interferon-beta gene expression.

Authors:  T Fujita; M Miyamoto; Y Kimura; J Hammer; T Taniguchi
Journal:  Nucleic Acids Res       Date:  1989-05-11       Impact factor: 16.971

8.  Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

Authors:  S Pellegrini; J John; M Shearer; I M Kerr; G R Stark
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

9.  Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

Authors:  D Watling; D Guschin; M Müller; O Silvennoinen; B A Witthuhn; F W Quelle; N C Rogers; C Schindler; G R Stark; J N Ihle
Journal:  Nature       Date:  1993-11-11       Impact factor: 49.962

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Authors:  K V Visvanathan; S Goodbourn
Journal:  EMBO J       Date:  1989-04       Impact factor: 11.598
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  6 in total

Review 1.  Biology and significance of the JAK/STAT signalling pathways.

Authors:  Hiu Kiu; Sandra E Nicholson
Journal:  Growth Factors       Date:  2012-02-20       Impact factor: 2.511

2.  A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes.

Authors:  D W Leaman; A Salvekar; R Patel; G C Sen; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

3.  Basal and reovirus-induced beta interferon (IFN-beta) and IFN-beta-stimulated gene expression are cell type specific in the cardiac protective response.

Authors:  Michael J Stewart; Kathleen Smoak; Mary Ann Blum; Barbara Sherry
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

4.  IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.

Authors:  Diana Saleiro; Gavin T Blyth; Ewa M Kosciuczuk; Patrick A Ozark; Beata Majchrzak-Kita; Ahmet D Arslan; Mariafausta Fischietti; Neha K Reddy; Curt M Horvath; Roger J Davis; Eleanor N Fish; Leonidas C Platanias
Journal:  Sci Signal       Date:  2018-11-20       Impact factor: 8.192

5.  Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.

Authors:  Pierre Génin; Rongtuan Lin; John Hiscott; Ahmet Civas
Journal:  Mol Cell Biol       Date:  2009-04-06       Impact factor: 4.272

6.  Isolation and characterization of a novel mutant mouse cell line resistant to Newcastle disease virus: constitutive interferon production and enhanced interferon sensitivity.

Authors:  K Aoki; M Oh-hira; M Hoshino; M Kawakita
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574
  6 in total

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